amitraz
Sign in to saveAlso known as Mitaban
Amitraz (development code BTS27419) is a non-systemic acaricide and insecticide and has also been described as a scabicide. It was first synthesized by the Boots Co. in England in 1969. Amitraz has been found to have an insect repellent effect, works as an insecticide and also as a pesticide synergist. Its effectiveness is traced back on alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis. Therefore, it leads to overexcitation and consequently paralysis and death in insects. Beca
Research
802 papers- Poisoning with amitraz.Toxicological reviews · 2003
- Amitraz, an underrecognized poison: A systematic review.The Indian journal of medical research · 2016
- Amitraz poisoning: A case report of an unusual pesticide poisoning in Sri Lanka and literature review.BMC pharmacology & toxicology · 2017
- Amitraz Resistance in French Varroa Mite Populations-More Complex Than a Single-Nucleotide Polymorphism.Insects · 2024
- Intravenous amitraz poisoning.Clinical toxicology (Philadelphia, Pa.) · 2005
via PubMed
Wikidata facts
- Mass
- 293.1892
Show 4 more facts
- chemical formula
- C₁₉H₂₃N₃
- canonical SMILES
- CC1=CC(=C(C=C1)N=CN(C=NC2=C(C=C(C=C2)C)C)C)C
- MCN code
- 2925.29.30
- Commons category
- Amitraz
via Wikidata · CC0
~17 min read
Article
16 sectionsContents
- Use
- Adverse effects
- Toxicity
- Human toxicity
- Treatment
- Non-human toxicity
- Synthesis
- Metabolism
- Kinetics
- Mechanism of action
- Alpha-adrenergic agonist activity
- Interaction with the octopamine receptor
- Inhibition of monoamine oxidases
- Inhibition of prostaglandin synthesis
- References
- External links
Amitraz (development code BTS27419) is a non-systemic acaricide and insecticide and has also been described as a scabicide. It was first synthesized by the Boots Co. in England in 1969. Amitraz has been found to have an insect repellent effect, works as an insecticide and also as a pesticide synergist. Its effectiveness is traced back on alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis. Therefore, it leads to overexcitation and consequently paralysis and death in insects. Because amitraz is less harmful to mammals, amitraz is among many other purposes best known as insecticide against mite- or tick-infestation of dogs. It is also widely used in the beekeeping industry as a control for the Varroa destructor mite, although there are reports of resistance.
== Use ==