Structure via PubChem · Public domain (PubChem)
nebivolol
Sign in to saveAlso known as R-65824, Ro-67555, 1,1'-bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2,2'-iminodiethanol, 1,1'-[bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)]-2,2'-iminodiethanol, alpha,alpha'-(iminodimethylene)bis-(6-fluoro-2-chromanmethanol), alpha,alpha'-(iminobismethylene)bis-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)
Nebivolol is a beta blocker used to treat high blood pressure and heart failure. As with other β-blockers, it is generally a less preferred treatment for high blood pressure. It may be used by itself or with other blood pressure medication. It is taken by mouth.
Chemical data
- Formula
- C22H25F2NO4
- Molecular weight
- 405.4 g/mol
- IUPAC name
- 1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]ethanol
- SMILES
- C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O
- InChIKey
- KOHIRBRYDXPAMZ-UHFFFAOYSA-N
- XLogP
- 3
- Polar surface area
- 71 Ų
- H-bond donors
- 3
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Research
1,306 papers- Nebivolol/Valsartan: A Novel Antihypertensive Fixed-Dose Combination Tablet.The Annals of pharmacotherapy · 2019
- Nebivolol in the treatment of arterial hypertension.Basic & clinical pharmacology & toxicology · 2019
- Clinical pharmacokinetics of nebivolol: a systematic review.Drug metabolism reviews · 2023
- Pharmacology of nebivolol.Pharmacological research · 1998
- Nebivolol/valsartan: Fixed-dose combination for treatment of hypertension.Drugs of today (Barcelona, Spain : 1998) · 2017
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 405.175165
- Has use
- medication
Show 8 more facts
- chemical formula
- C₂₂H₂₅F₂NO₄
- Commons category
- Nebivolol
- World Health Organisation international non-proprietary name
- nebivolol
- canonical SMILES
- C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O
- subject has role
- vasodilator agent
- defined daily dose
- 5
- medical condition treated
- arterial hypertension
- significant drug interaction
- disopyramide
via Wikidata · CC0
~9 min read
Encyclopedic overview
17 sectionsContents
- Medical uses
- Contraindications
- Side effects
- Interactions
- Pharmacology
- Pharmacodynamics
- β<sub>1</sub>-selectivity
- Vasodilator action
- Antihypertensive effect
- Pharmacokinetics
- Chemistry
- Society and culture
- Brand names and marketing
- Controversies
- Tolerability claims
- FDA warning letter about advertising claims
- References
Nebivolol is a beta blocker used to treat high blood pressure and heart failure. As with other β-blockers, it is generally a less preferred treatment for high blood pressure. It may be used by itself or with other blood pressure medication. It is taken by mouth.
thumb|A bottle of 20mg nebivolol tablets
Excerpted from Wikipedia’s “nebivolol” article, available under the CC BY-SA 4.0 licence.