ANGPT2

Name

angiopoietin 2

Type

protein-coding

Position

6,499,632–6,563,409 (−)

Aliases

AGPT2, ANG2, LMPHM10

Ensembl

ENSG00000091879

RefSeq RNA

NM_001118887.2, NM_001118888.2, NM_001147.3, NM_001386335.1, NM_001386336.1

RefSeq protein

NP_001112359.1, NP_001112360.1, NP_001138.1, NP_001373264.1, NP_001373265.1

This gene belongs to the angiopoietin family of growth factors. The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis. This gene serves a prognostic biomarker for acute respiratory distress syndrome. [provided by RefSeq, Aug 2020].

via MyGene.info

Gene · Ensembl

angiopoietin 2

Symbol

ANGPT2

Biotype

Protein coding

Organism

Homo sapiens

Location

8:6,499,632-6,563,436

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

Protein ANGPT2 PDB 1z3s.png

via Wikidata · CC0