TEK

Also known as TIE2, VMCM, CD202B, TIE-2, VMCM1, TEK tyrosine kinase, TEK receptor tyrosine kinase, GLC3E

protein-coding gene in the species Homo sapiens

Gene data

TEK

Name: TEK receptor tyrosine kinase
Type: protein-coding
Position: 27,109,030–27,232,092 (+)
Aliases: CD202B, GLC3E, TIE-2, TIE2, VMCM, VMCM1
Ensembl: ENSG00000120156
RefSeq RNA: NM_000459.5, NM_001290077.2, NM_001290078.2, NM_001375475.1, NM_001375476.1
RefSeq protein: NP_000450.3, NP_001277006.2, NP_001277007.2, NP_001362404.1, NP_001362405.1

This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014].