anisomycin
Sign in to saveAlso known as 2-p-Methoxyphenylmethyl-3-acetoxy-4-hydroxypyrrolidine, 2-(p-Methoxybenzyl)-3,4-pyrrolidinediol 3-acetate, 1,4,5-Trideoxy-1,4-imino-5-(p-methoxyphenyl)-D-xylo-pentitol 3-acetate
Anisomycin, also known as flagecidin, is an antibiotic produced by Streptomyces griseolus which inhibits eukaryotic protein synthesis. Partial inhibition of DNA synthesis occurs at anisomycin concentrations that effect 95% inhibition of protein synthesis. Anisomycin can activate stress-activated protein kinases, MAP kinase and other signal transduction pathways.
Wikidata facts
- Mass
- 265.131
Show 4 more facts
- chemical formula
- C₁₄H₁₉NO₄
- isomeric SMILES
- CC(=O)O[C@@H]1[C@H](CN[C@@H]1CC2=CC=C(C=C2)OC)O
- canonical SMILES
- CC(=O)OC1C(CNC1CC2=CC=C(C=C2)OC)O
- Commons category
- Anisomycin
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Article
5 sectionsContents
- Pharmacology
- Biosynthesis
- Other uses
- See also
- References
Anisomycin, also known as flagecidin, is an antibiotic produced by Streptomyces griseolus which inhibits eukaryotic protein synthesis. Partial inhibition of DNA synthesis occurs at anisomycin concentrations that effect 95% inhibition of protein synthesis. Anisomycin can activate stress-activated protein kinases, MAP kinase and other signal transduction pathways.
==Pharmacology== Anisomycin interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.