APBB2
Sign in to saveAlso known as FE65L, FE65L1, amyloid beta precursor protein binding family B member 2
gen van de soort Homo sapiens
Gene data
APBB2- Name
- amyloid beta precursor protein binding family B member 2
- Type
- protein-coding
- Position
- 40,810,027–41,216,714 (−)
- Aliases
- FE65L, FE65L1
- Ensembl
- ENSG00000163697
- RefSeq RNA
- NM_001166050.2, NM_001166051.2, NM_001166052.2, NM_001166053.1, NM_001166054.1
- RefSeq protein
- NP_001159522.1, NP_001159523.1, NP_001159524.1, NP_001159525.1, NP_001159526.1
The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
Gene Ontology
Biological process
negative regulation of transcription by RNA polymerase IIregulation of DNA-templated transcriptionsmooth muscle contractionintracellular signal transductionmaintenance of lens transparencypositive regulation of transcription by RNA polymerase IIsynapse organizationnegative regulation of cell cycle phase transition
via MyGene.info
Gene · Ensembl
amyloid beta precursor protein binding family B member 2
- Symbol
- APBB2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:40,810,027-41,216,714
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein APBB2 PDB 1wgu.png
Show 9 more facts
- HomoloGene ID
- 32079
- genetic association
- dental caries
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/323
- genomic end
- 41218731
- genomic start
- 40812044
- chromosome
- human chromosome 4
- cytogenetic location
- 4p14-p13
- expressed in
- tibia
via Wikidata · CC0