Structure via PubChem · Public domain (PubChem)
artemether
Sign in to saveAlso known as Artemetheri, beta-Artemether, (1R,4S,5R,8S,9R,10S,12R,13R)-10-Methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecane, Dihydroqinghaosu methyl ether, Artemisininelactol methyl ether, Methyl-dihydroartemisinine, Artemetero, SM-224
Artemether is a medication used for the treatment of malaria. The injectable form is specifically used for severe malaria rather than quinine. In adults, it may not be as effective as artesunate. It is given by injection in a muscle. It is also available by mouth in combination with lumefantrine, known as artemether/lumefantrine.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 457818137
- Drug.IUPAC_name
- (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]-2-benzopyran
- Drug.image
- artemether.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 150
- Drug.image2
- Artemether ball-and-stick model from xtal 2007.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 200
- Drug.tradename
- Many
- Drug.pregnancy_US
- C
- Drug.legal_UK
- POM
- Drug.legal_status
- Rx only
- Drug.routes_of_administration
- Intramuscular Oral
- Drug.CAS_number
- 71963-77-4
- Drug.ATC_prefix
- P01
- Drug.ATC_suffix
- BE02
via Wikipedia infobox
Chemical data
- Formula
- C16H26O5
- Molecular weight
- 298.37 g/mol
- IUPAC name
- (1R,4S,5R,8S,9R,10S,12R,13R)-10-methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecane
- SMILES
- C[C@@H]1CC[C@H]2[C@H]([C@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)OC)C
- InChIKey
- SXYIRMFQILZOAM-HVNFFKDJSA-N
- XLogP
- 3.1
- Polar surface area
- 46.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
2,914 papers- Artemether for severe malaria.The Cochrane database of systematic reviews · 2019
- Artemether for severe malaria.The Cochrane database of systematic reviews · 2014
- Artemether-lumefantrine for uncomplicated malaria: a systematic review.Tropical medicine & international health : TM & IH · 2004
- Artemether ameliorates DSS-induced ulcerative colitis by modulating macrophage polarization.International immunopharmacology · 2025
- Artemether ameliorates adriamycin induced cardiac atrophy in mice.Molecular medicine reports · 2023
via PubMed
Wikidata facts
- Mass
- 298.178
Show 4 more facts
- chemical formula
- C₁₆H₂₆O₅
- isomeric SMILES
- C[C@@H]1CC[C@H]2[C@H]([C@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)OC)C
- canonical SMILES
- CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC)C
- World Health Organisation international non-proprietary name
- artemether
via Wikidata · CC0
~4 min read
Article
8 sectionsContents
- Medical uses
- Side effects
- Drug interactions
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Chemistry
- References
Artemether is a medication used for the treatment of malaria. The injectable form is specifically used for severe malaria rather than quinine. In adults, it may not be as effective as artesunate. It is given by injection in a muscle. It is also available by mouth in combination with lumefantrine, known as artemether/lumefantrine.
Artemether causes relatively few side effects. An irregular heartbeat may rarely occur. While there is evidence that use during pregnancy may be harmful in animals, there is no evidence of concern in humans. The World Health Organization (WHO) therefore recommends its use during pregnancy. It is in the artemisinin class of medication.