Structure via PubChem · Public domain (PubChem)
artesunate
Sign in to saveAlso known as Arsumax, artesunato, artesunatum, artesunic acid, AS, butanedioic acid, 1-[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] ester, dihydroqinghasu hemsuccinate
Artesunate is a medication used to treat malaria. The intravenous form is preferred to quinine for severe malaria. Often it is used as part of combination therapy, such as artesunate plus mefloquine. It is not used for the prevention of malaria. Artesunate can be given by injection into a vein, injection into a muscle, by mouth, and by rectum.
Key facts
- Drug.image
- Artesunate.svg
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 457818909
- Drug.image_class
- skin-invert-image
- Drug.image2
- Artesunate ball-and-stick model from xtal 2002.png
- Drug.image_class2
- bg-transparent
- Drug.pronounce
- ahr-tez′ŭ-nāt
- Drug.tradename
- many
- Drug.DailyMedID
- Artesunate
- Drug.routes_of_administration
- By mouth, intravenous, intramuscular
- Drug.class
- Artemisinin
- Drug.ATC_prefix
- P01
- Drug.ATC_suffix
- BE03
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.index2_label
- as salt
via Wikipedia infobox
Chemical data
- Formula
- C19H28O8
- Molecular weight
- 384.4 g/mol
- IUPAC name
- 4-oxo-4-[[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]oxy]butanoic acid
- SMILES
- C[C@@H]1CC[C@H]2[C@H]([C@@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)OC(=O)CCC(=O)O)C
- InChIKey
- FIHJKUPKCHIPAT-AHIGJZGOSA-N
- XLogP
- 2.5
- Polar surface area
- 101 Ų
- H-bond donors
- 1
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Research
4,462 papers- Artesunate Sensitizes human hepatocellular carcinoma to sorafenib via exacerbating AFAP1L2-SRC-FUNDC1 axis-dependent mitophagy.Autophagy · 2024
- Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma.Acta pharmacologica Sinica · 2021
- Artesunate Inhibits the Cell Growth in Colorectal Cancer by Promoting ROS-Dependent Cell Senescence and Autophagy.Cells · 2022
- Artesunate: A review of its therapeutic insights in respiratory diseases.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2022
- IV artesunate for severe malaria.The Medical letter on drugs and therapeutics · 2020
via PubMed
~10 min read
Encyclopedic overview
12 sectionsContents
- Medical uses
- Pregnancy
- Children
- Adverse effects
- Contraindications
- Mechanisms of action
- Pharmacokinetics
- Chemical synthesis
- Research
- History
- References
- External links
Artesunate is a medication used to treat malaria. The intravenous form is preferred to quinine for severe malaria. Often it is used as part of combination therapy, such as artesunate plus mefloquine. It is not used for the prevention of malaria. Artesunate can be given by injection into a vein, injection into a muscle, by mouth, and by rectum.
The most common side effects include kidney failure requiring dialysis, hemoglobinuria (the presence of hemoglobin in urine) and jaundice.
Excerpted from Wikipedia’s “artesunate” article, available under the CC BY-SA 4.0 licence.