File:Mouse_with_spinal_muscular_atrophy.jpg · Wikimedia Commons · See Wikimedia Commons
atrophy
Sign in to saveAtrophy is the partial or complete wasting away of a part of the body. Causes of atrophy include mutations (which can destroy the gene to build up the organ), poor nourishment, poor circulation, loss of hormonal support, loss of nerve supply to the target organ, excessive amount of apoptosis of cells, and disuse or lack of exercise or disease intrinsic to the tissue itself. In medical practice, hormonal and nerve inputs that maintain an organ or body part are said to have trophic effects. A diminished muscular trophic condition is designated as atrophy. Atrophy is reduction in size of cell, or
Key facts
- Medical condition (new).name
- Atrophy
- Medical condition (new).image
- Mouse_with_spinal_muscular_atrophy.jpg
- Medical condition (new).caption
- Mouse (right) with spinal muscular atrophy
- Medical condition (new).field
- Pathology
- Medical condition (new).symptoms
- Loss of body cells, signs of ageing
- Medical condition (new).types
- Muscular atrophy, gland atrophy
- Medical condition (new).causes
- Poor nourishment, poor circulation, loss of hormonal support, loss of nerve supply to target organ(s), excessive apoptosis of cells, insufficient exercise, ageing
- Medical condition (new).risks
- Old age, sedentary lifestyle
- Medical condition (new).prognosis
- Depends on the cause
via Wikipedia infobox
Research
175,277 papers- Noncoding RNAs in Muscle Atrophy.Advances in experimental medicine and biology · 2018
- Olivopontocerebellar atrophy.Neurology · 1956
- Deubiquitinases in skeletal muscle atrophy.The international journal of biochemistry & cell biology · 2013
- Infantile muscular atrophy.Archives of neurology · 1961
- Thalamic nuclei atrophy at high and heterogenous rates during cognitively unimpaired human aging.NeuroImage · 2022
via PubMed
Clinical Trials
4,843 registered- NAUNKNOWNLaser Therapy for Vulvovaginal Symptoms in Breast Cancer PatientsRoyal North Shore Hospital · NCT03628092
- PHASE2ACTIVE_NOT_RECRUITINGPhase 2 Study of EDG-5506 in Children and Adolescents With Duchenne Muscular Dystrophy Previously Treated With Gene TherapyEdgewise Therapeutics, Inc. · NCT06100887
- TERMINATEDGlobal Atrophie Biomarker Evaluation Study (GABiE)Boehringer Ingelheim · NCT03935126
- NACOMPLETEDOsteoclast Impairment in Chronic Periodontitis by Regenerative Materials.Meenakshi Ammal Dental College and Hospital · NCT03227367
- COMPLETEDNatural History of Geographic Atrophy Associated With Age-Related Macular DegenerationNational Eye Institute (NEI) · NCT02941263
- NARECRUITINGEffectiveness of a Structured Multidimensional Tele-rehabilitation Intervention in Cardiac Patients With Post-Intensive Care Syndrome (CARDIO-PICS)Fondazione Don Carlo Gnocchi Onlus · NCT07599306
Wikidata facts
- Image
- Mouse with spinal muscular atrophy.jpg
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- Commons category
- Atrophy
Sources (7)
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Article
9 sectionsContents
- Normal development
- Muscle atrophies
- Dystrophies, myositis, and motor neuron conditions
- Gland atrophy
- Vaginal atrophy
- Research
- See also
- References
- External links
Atrophy is the partial or complete wasting away of a part of the body. Causes of atrophy include mutations (which can destroy the gene to build up the organ), poor nourishment, poor circulation, loss of hormonal support, loss of nerve supply to the target organ, excessive amount of apoptosis of cells, and disuse or lack of exercise or disease intrinsic to the tissue itself. In medical practice, hormonal and nerve inputs that maintain an organ or body part are said to have trophic effects. A diminished muscular trophic condition is designated as atrophy. Atrophy is reduction in size of cell, organ or tissue, after attaining its normal mature growth. In contrast, hypoplasia is the reduction in the cellular numbers of an organ, or tissue that has not attained normal maturity.
Atrophy is the general physiological process of reabsorption and breakdown of tissues, involving apoptosis. When it occurs as a result of disease or loss of trophic support because of other diseases, it is termed pathological atrophy, although it can be a part of normal body development and homeostasis as well.