bezitramide
Sign in to saveAlso known as R-4845, 1-[1-(3-cyano-3,3-diphenylpropyl)-4-piperidinyl]-1,3-dihydro-3-(1-oxopropyl)-2H-benzimidazol-2-one
Bezitramide is an opioid analgesic. Bezitramide itself is a prodrug which is readily hydrolyzed in the gastrointestinal tract to its active metabolite, despropionyl-bezitramide. Bezitramide was discovered at Janssen Pharmaceutica in 1961. It is most commonly marketed under the trade name Burgodin.
Research
25 papers- [Pharmacology of bezitramide].Nederlands tijdschrift voor geneeskunde · 1970
- Experience with bezitramide and droperidol in the treatment of severe chronic pain.British journal of anaesthesia · 1972
- Quantitative analysis of despropionyl-bezitramide, the active metabolite of bezitramide (Burgodin), in biological samples by high-performance liquid chromatography with fluorescence detection.Analytical chemistry · 1997
- Bezitramide, an orally active analgesic. An investigation on pain following operations for lumbar disc protrusion (preliminary report).British journal of anaesthesia · 1970
- Bezitramide (R 4845), a new potent and orally long-acting analgesic compound.Arzneimittel-Forschung · 1971
via PubMed
Wikidata facts
- Mass
- 492.253
Show 4 more facts
- chemical formula
- C₃₁H₃₂N₄O₂
- World Health Organisation international non-proprietary name
- bezitramide
- canonical SMILES
- CCC(=O)N1C2=CC=CC=C2N(C1=O)C3CCN(CC3)CCC(C#N)(C4=CC=CC=C4)C5=CC=CC=C5
- defined daily dose
- 15
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Article
2 sectionsContents
- See also
- References
Bezitramide is an opioid analgesic. Bezitramide itself is a prodrug which is readily hydrolyzed in the gastrointestinal tract to its active metabolite, despropionyl-bezitramide. Bezitramide was discovered at Janssen Pharmaceutica in 1961. It is most commonly marketed under the trade name Burgodin.
The drug was pulled from the shelves in the Netherlands in 2004 after fatal overdose cases, including one where a five-year-old child took one tablet from his mother's purse, ate it, and promptly died.