結合位點
Sign in to saveAlso known as binding sites, binding pocket, substrate binding site, substrate binding pocket
region on a protein or piece of DNA or RNA to which ligands may form a chemical interaction
Research
627,835 papers- Binding site comparisons for target-centered drug discovery.Expert opinion on drug discovery · 2019
- DeepPocket: Ligand Binding Site Detection and Segmentation using 3D Convolutional Neural Networks.Journal of chemical information and modeling · 2022
- Computational methods for binding site prediction on macromolecules.Quarterly reviews of biophysics · 2025
- Indole derivatives targeting colchicine binding site as potential anticancer agents.Archiv der Pharmazie · 2023
- Computational Ligand-Binding Site Prediction.Advances in experimental medicine and biology · 2026
via PubMed
Article · 中文
在生物化学和分子生物学中，结合位点是大分子（如蛋白质）上的一个区域，它与另一个具有特异性的分子结合。大分子的结合伙伴通常被称为配体。配体可以包括其他蛋白质（导致蛋白质交互作用）、、第二信使、激素或变构调节剂。结合事件经常，但并不总是伴随着构象变化，从而改变蛋白质的功能。与蛋白质结合位点的结合通常是可逆的（瞬时和非共价），但也可以是共价可逆或不可逆的。
Abstract from DBpedia / Wikipedia · CC BY-SA