BIRC7

Also known as KIAP, LIVIN, ML-IAP, MLIAP, RNF50, baculoviral IAP repeat containing 7

Baculoviral IAP repeat-containing protein 7 is a protein that in humans is encoded by the BIRC7 gene.

Gene data

BIRC7

Name: baculoviral IAP repeat containing 7
Type: protein-coding
Aliases: KIAP, LIVIN, ML-IAP, MLIAP, RNF50

This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013].

via MyGene.info

Gene · Ensembl

baculoviral IAP repeat containing 7

Symbol: BIRC7
Biotype: Protein coding
Organism: Homo sapiens
Location: 20:63,235,435-63,240,497
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein BIRC7 PDB 1oxn.png

Show 5 more facts

HomoloGene ID: 51405
exact match: identifiers.org/ncbigene/79444
genomic end: 63240495
genomic start: 61867235
cytogenetic location: 20q13.33

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Baculoviral IAP repeat-containing protein 7 is a protein that in humans is encoded by the BIRC7 gene.

The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide. In melanoma, BIRC7 gene expression is regulated by the Microphthalmia-associated transcription factor.