BNIP3

Also known as NIP3, BCL2/adenovirus E1B 19kDa interacting protein 3, BCL2 interacting protein 3, HABON

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 is a protein found in humans that is encoded by the BNIP3 gene.

Gene data

BNIP3

Name: BCL2 interacting protein 3
Type: protein-coding
Position: 131,966,461–131,981,984 (−)
Aliases: HABON, NIP3
Ensembl: ENSG00000176171
RefSeq RNA: NM_004052.4
RefSeq protein: NP_004043.4

This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014].

Gene Ontology

Biological process

autophagy of mitochondrion mitophagy mitophagy

~7 min read

Article

13 sections

Contents

Structure
Function
Transport reaction
Autophagy
Autophagic cell death
NK cell memory formation
Activities in the mitochondrial membrane
Integration
Activation
Interactions
References
Further reading
External links

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 is a protein found in humans that is encoded by the BNIP3 gene.

BNIP3 is a member of the apoptotic Bcl-2 protein family. It can induce cell death while also assisting with cell survival. Like many of the Bcl-2 family proteins, BNIP3 modulates the permeability state of the outer mitochondrial membrane by forming homo- and hetero-oligomers inside the membrane. Upregulation results in a decrease in mitochondrial potential, an increase in reactive oxygen species, mitochondrial swelling and fission, and an increase in mitochondrial turnover via autophagy. Sequence similarity with Bcl-2 family members was not detected. Humans and other animals (Drosophila, Caenorhabditis), as well as lower eukaryotes (Dictyostelium, Trypanosoma, Cryptosporidium, Paramecium) encode several BNIP3 paralogues including the human NIP3L, which induces apoptosis by interacting with viral and cellular anti-apoptosis proteins.