bosentan

Also known as RO 47-0203, Tracleer®, p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide, 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide, bosentan anhydrous, bosentán, bosentanum

Bosentan, sold under the brand name Tracleer among others, is a dual endothelin receptor antagonist medication used in the treatment of pulmonary artery hypertension (PAH).

Wikidata facts

Mass: 551.183855

Show 4 more facts

chemical formula: C₂₇H₂₉N₅O₆S
canonical SMILES: CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=NC=CC=N3)OCCO)OC4=CC=CC=C4OC
World Health Organisation international non-proprietary name: bosentan
defined daily dose: 0.25

Sources (6)

via Wikidata · CC0

~4 min read

Article

10 sections

Contents

Medical uses
Contraindications
Adverse effects
Drug interactions
Mechanism of action
Pharmacokinetics
History
Society and culture
Economics
References

Bosentan, sold under the brand name Tracleer among others, is a dual endothelin receptor antagonist medication used in the treatment of pulmonary artery hypertension (PAH).

Bosentan is available as film-coated tablets (62.5 mg or 125 mg) or as dispersible tablets for oral suspension (32 mg).