Structure via PubChem · Public domain (PubChem)
bromazolam
Sign in to savethumb|Bromazolam 3 mg pellet (tablet) Bromazolam (XLI-268) is a triazolobenzodiazepine (TBZD) which was first synthesised in 1976, but was never marketed. It has subsequently been sold as a designer drug, first being definitively identified by the EMCDDA in Sweden in 2016. It is the bromo instead of chloro analogue of alprazolam and has similar sedative and anxiolytic effects to it and other benzodiazepines. Bromazolam is a non subtype selective agonist at the benzodiazepine site of GABAA receptors, with a binding affinity of 2.81 nM at the α1 subtype, 0.69 nM at α2 and 0.62 nM
Chemical data
- Formula
- C17H13BrN4
- Molecular weight
- 353.2 g/mol
- IUPAC name
- 8-bromo-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
- SMILES
- CC1=NN=C2N1C3=C(C=C(C=C3)Br)C(=NC2)C4=CC=CC=C4
- InChIKey
- KCEIOBKDDQAYCM-UHFFFAOYSA-N
- XLogP
- 2.2
- Polar surface area
- 43.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
Show 2 more facts
- chemical formula
- C₁₇H₁₃BrN₄
- Commons category
- Bromazolam
via Wikidata · CC0
~9 min read
Encyclopedic overview
13 sectionsContents
- Adverse effects
- Pharmacology
- Pharmacokinetics
- Metabolism
- Phase I
- Phase II
- Pharmacodynamics
- Chemistry
- Synthesis
- Society and culture
- Legal status
- See also
- References
thumb|Bromazolam 3 mg pellet (tablet) Bromazolam (XLI-268) is a triazolobenzodiazepine (TBZD) which was first synthesised in 1976, but was never marketed. It has subsequently been sold as a designer drug, first being definitively identified by the EMCDDA in Sweden in 2016. It is the bromo instead of chloro analogue of alprazolam and has similar sedative and anxiolytic effects to it and other benzodiazepines. Bromazolam is a non subtype selective agonist at the benzodiazepine site of GABAA receptors, with a binding affinity of 2.81 nM at the α1 subtype, 0.69 nM at α2 and 0.62 nM at α5. The "common" dosage range for users of bromazolam was reported to be 1–2 mg, suggesting its potency is similar to alprazolam.
== Adverse effects ==
Excerpted from Wikipedia’s “bromazolam” article, available under the CC BY-SA 4.0 licence.