Structure via PubChem · Public domain (PubChem)
buspirone
Sign in to saveAlso known as Buspar®, MJ-9022-1, 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione, Buspirona, Buspironum, Buspiron
Buspirone, sold under the name Buspar among others, is an anxiolytic medication primarily used for the treatment of generalized anxiety disorder. Unlike benzodiazepines, buspirone does not produce significant sedation, dependence, or withdrawal symptoms.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 459522704
- Drug.image
- Buspirone 200.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 250
- Drug.image2
- Buspirone 3D structure.png
- Drug.image_class2
- bg-transparent
- Drug.pronounce
- ()
- Drug.tradename
- Buspar, others
- Drug.MedlinePlus
- a688005
- Drug.DailyMedID
- Buspirone
- Drug.pregnancy_AU
- B1
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- N05
- Drug.ATC_suffix
- BE01
- Drug.legal_AU
- S4
- Drug.legal_BR
- C1
- Drug.legal_CA
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C21H31N5O2
- Molecular weight
- 385.5 g/mol
- IUPAC name
- 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione
- SMILES
- C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4
- InChIKey
- QWCRAEMEVRGPNT-UHFFFAOYSA-N
- XLogP
- 2.6
- Polar surface area
- 69.6 Ų
- H-bond donors
- 0
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Research
3,264 papers- Buspirone: future directions.Journal of clinical psychopharmacology · 1999
- Buspirone in clinical practice.The Journal of clinical psychiatry · 1990
- Buspirone: Back to the Future.Journal of psychosocial nursing and mental health services · 2015
- Buspirone: a worldwide update.The British journal of psychiatry. Supplement · 1991
- Late-stage-functionalization of anti-depressant molecule buspirone.Molecular diversity · 2025
via PubMed
Wikidata facts
- Mass
- 385.248
Show 6 more facts
- chemical formula
- C₂₁H₃₁N₅O₂
- Commons category
- Buspirone
- canonical SMILES
- C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4
- World Health Organisation international non-proprietary name
- buspirone
- defined daily dose
- 30
- stylized name
- busPIRone
via Wikidata · CC0
~14 min read
Article
22 sectionsContents
- Medical uses
- Anxiety
- Other uses
- Sexual dysfunction
- Miscellaneous
- Contraindications
- Side effects
- Overdose
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- Analogues
- Synthesis
- History
- Society and culture
- Generic names
- Brand names
- See also
- References
- External links
{{Infobox drug | Watchedfields = changed | verifiedrevid = 459522704 | image = Buspirone 200.svg | image_class = skin-invert-image | width = 250 | alt = | image2 = Buspirone 3D structure.png | image_class2 = bg-transparent | alt2 =
| pronounce = () | tradename = Buspar, others | Drugs.com = | MedlinePlus = a688005 | DailyMedID = Buspirone | pregnancy_AU = B1 | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = By mouth | class = | ATC_prefix = N05 | ATC_suffix = BE01 | ATC_supplemental =