CA9

Name

carbonic anhydrase 9

Type

protein-coding

Aliases

CAIX, MN

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jun 2014].

via MyGene.info

Gene · Ensembl

carbonic anhydrase 9

Symbol

CA9

Biotype

Protein coding

Organism

Homo sapiens

Location

9:35,673,898-35,681,159

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein CA9 PDB 2HKF.png

via Wikidata · CC0