CALCOCO2

Also known as NDP52, calcium binding and coiled-coil domain 2

Calcium-binding and coiled-coil domain-containing protein 2 is a protein that in humans is encoded by the CALCOCO2 gene.

Gene data

CALCOCO2

Name: calcium binding and coiled-coil domain 2
Type: protein-coding
Position: 48,830,971–48,868,228 (+)
Aliases: NDP52
Ensembl: ENSG00000136436
RefSeq RNA: NM_001261390.2, NM_001261391.2, NM_001261393.2, NM_001261395.2, NM_005831.5
RefSeq protein: NP_001248319.1, NP_001248320.1, NP_001248322.1, NP_001248324.1, NP_005822.1

This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].

Gene Ontology

Biological process

viral process response to type II interferon xenophagy xenophagy positive regulation of autophagosome maturation positive regulation of autophagosome maturation

Molecular function

protein binding protein homodimerization activity

Cellular component

autophagosome membrane nucleus cytoplasm autophagosome autophagosome cytosol cytoskeleton membrane

Pathways

Mitophagy - animal - Homo sapiens (human)Shigellosis - Homo sapiens (human)Influenza A - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

calcium binding and coiled-coil domain 2

Symbol: CALCOCO2
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:48,830,971-48,872,910
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 31339
exact match: identifiers.org/ncbigene/10241
genomic end: 46943884
genomic start: 48831018
cytogenetic location: 17q21.32

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Calcium-binding and coiled-coil domain-containing protein 2 is a protein that in humans is encoded by the CALCOCO2 gene.

The protein encoded by this gene is a subunit of nuclear domain 10 (ND10) bodies. ND10 bodies are nuclear domains appearing immunohistochemically as ten dots per nucleus. They are believed to be associated with the nuclear matrix on the basis of their resistance to nuclease digestion and salt extraction. ND10 proteins are removed from the nucleus by HSV-1 infection and may have a role in viral life cycles.