CALCOCO2

Also known as NDP52, calcium binding and coiled-coil domain 2

Calcium-binding and coiled-coil domain-containing protein 2 is a protein that in humans is encoded by the CALCOCO2 gene.

Gene data

CALCOCO2

Name: calcium binding and coiled-coil domain 2
Type: protein-coding
Position: 48,830,971–48,868,228 (+)
Aliases: NDP52
Ensembl: ENSG00000136436
RefSeq RNA: NM_001261390.2, NM_001261391.2, NM_001261393.2, NM_001261395.2, NM_005831.5
RefSeq protein: NP_001248319.1, NP_001248320.1, NP_001248322.1, NP_001248324.1, NP_005822.1

This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].

Gene Ontology

Biological process

viral process response to type II interferon

Article

3 sections

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References
Further reading
External links

Calcium-binding and coiled-coil domain-containing protein 2 is a protein that in humans is encoded by the CALCOCO2 gene.

The protein encoded by this gene is a subunit of nuclear domain 10 (ND10) bodies. ND10 bodies are nuclear domains appearing immunohistochemically as ten dots per nucleus. They are believed to be associated with the nuclear matrix on the basis of their resistance to nuclease digestion and salt extraction. ND10 proteins are removed from the nucleus by HSV-1 infection and may have a role in viral life cycles.