Gene data
CBLC- Name
- Cbl proto-oncogene C
- Type
- protein-coding
- Position
- 44,777,845–44,802,301 (+)
- Aliases
- CBL-3, CBL-SL, RNF57
- Ensembl
- ENSG00000142273
- RefSeq RNA
- NM_001130852.1, NM_012116.4, XM_005258696.4, XM_011526688.3, XM_011526689.3
- RefSeq protein
- NP_001124324.1, NP_036248.3, XP_005258753.1, XP_011524990.1, XP_011524991.1
This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012].
Gene Ontology
Biological process
ubiquitin-dependent protein catabolic processsignal transductioncell surface receptor signaling pathwayprotein ubiquitinationregulation of signalingprotein catabolic processnegative regulation of epidermal growth factor receptor signaling pathwaynegative regulation of epidermal growth factor receptor signaling pathway
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
Cbl proto-oncogene C
- Symbol
- CBLC
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:44,777,845-44,802,301
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 8108
- exact match
- identifiers.org/ncbigene/23624
- found in taxon
- Homo sapiens
- genomic end
- 44800652
- genomic start
- 45281126
- chromosome
- human chromosome 19
- cytogenetic location
- 19q13.32
Sources (4)
via Wikidata · CC0