CBLC

Also known as CBL-3, CBL-SL, RNF57, Cbl proto-oncogene C

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.

Gene data

CBLC

Name: Cbl proto-oncogene C
Type: protein-coding
Aliases: CBL-3, CBL-SL, RNF57

This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012].

via MyGene.info

Gene · Ensembl

Cbl proto-oncogene C

Symbol: CBLC
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:44,777,845-44,802,301
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

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HomoloGene ID: 8108
exact match: identifiers.org/ncbigene/23624
genomic end: 44800652
genomic start: 45281126
cytogenetic location: 19q13.32

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Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.

CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).[supplied by OMIM]