CBLC

Also known as CBL-3, CBL-SL, RNF57, Cbl proto-oncogene C

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.

In the Vinony graph

Within Vinony's link graph, CBLC is referenced by 5 other articles, and connects out to PubMed, human chromosome 19 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 19.

Its subject is documented across 5 Wikipedia language editions.

Gene data

CBLC

Name: Cbl proto-oncogene C
Type: protein-coding
Position: 44,777,845–44,802,301 (+)
Aliases: CBL-3, CBL-SL, RNF57
Ensembl: ENSG00000142273
RefSeq RNA: NM_001130852.1, NM_012116.4, XM_005258696.4, XM_011526688.3, XM_011526689.3
RefSeq protein: NP_001124324.1, NP_036248.3, XP_005258753.1, XP_011524990.1, XP_011524991.1

This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012].

Gene Ontology

Biological process

ubiquitin-dependent protein catabolic process signal transduction cell surface receptor signaling pathway protein ubiquitination regulation of signaling protein catabolic process negative regulation of epidermal growth factor receptor signaling pathway negative regulation of epidermal growth factor receptor signaling pathway

Molecular function

phosphotyrosine residue binding phosphotyrosine residue binding ubiquitin-protein transferase activity epidermal growth factor receptor binding calcium ion binding protein binding zinc ion binding SH3 domain binding

Cellular component

plasma membrane membrane raft

Pathways

Ubiquitin mediated proteolysis - Homo sapiens (human)Endocytosis - Homo sapiens (human)Angiopoietin Like Protein 8 Regulatory Pathway EGF-EGFR signaling pathway Insulin Signaling

via MyGene.info

Gene · Ensembl

Cbl proto-oncogene C

Symbol: CBLC
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:44,777,845-44,802,301
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 8108
exact match: identifiers.org/ncbigene/23624
found in taxon: Homo sapiens
genomic end: 44800652
genomic start: 45281126
chromosome: human chromosome 19
cytogenetic location: 19q13.32

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Interactions
References
External links
Further reading

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.

CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).[supplied by OMIM]

Excerpted from Wikipedia’s “CBLC” article, available under the CC BY-SA 4.0 licence.