BCCIP

Also known as TOK-1, TOK1, BRCA2 and CDKN1A interacting protein

BRCA2 and CDKN1A-interacting protein is a protein that is encoded by the BCCIP gene in humans.

Gene data

BCCIP

Name: BRCA2 and CDKN1A interacting protein
Type: protein-coding
Aliases: TOK-1, TOK1

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

BRCA2 and CDKN1A interacting protein

Symbol: BCCIP
Biotype: Protein coding
Organism: Homo sapiens
Location: 10:125,823,523-125,854,471
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 41629
exact match: identifiers.org/ncbigene/56647
genomic start: 127512115
genomic end: 127542264
cytogenetic location: 10q26.2

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Further reading

BRCA2 and CDKN1A-interacting protein is a protein that is encoded by the BCCIP gene in humans.

This gene product was isolated based on its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. Several transcript variants encoding different isoforms have been described for this gene.