CLCA2
Sign in to saveAlso known as CACC, CACC3, CLCRG2, CaCC-3, chloride channel accessory 2
Chloride channel accessory 2 is a protein that in humans is encoded by the CLCA2 gene.
Gene data
CLCA2- Name
- chloride channel accessory 2
- Type
- protein-coding
- Position
- 86,424,171–86,456,553 (+)
- Aliases
- CACC, CACC3, CLCRG2, CaCC-3
- Ensembl
- ENSG00000137975
- RefSeq RNA
- NM_006536.7, XM_011542448.4, XM_054339725.1
- RefSeq protein
- NP_006527.1, XP_011540750.1, XP_054195700.1
This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines. [provided by RefSeq, Sep 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
chloride channel accessory 2
- Symbol
- CLCA2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:86,423,483-86,456,553
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 4765
- exact match
- identifiers.org/ncbigene/9635
- genomic end
- 86456553
- genomic start
- 86424171
- cytogenetic location
- 1p22.3
Sources (4)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- See also
- References
- Further reading
- External links
Chloride channel accessory 2 is a protein that in humans is encoded by the CLCA2 gene.
The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer. Protein structure prediction methods suggest the N-terminal region of CLCA2 protein is a zinc metalloprotease.