CLIC2
Sign in to saveAlso known as CLIC2b, MRXS32, XAP121, chloride intracellular channel 2, CLCNL2
Chloride intracellular channel protein 2 is a protein that in humans is encoded by the CLIC2 gene.
Gene data
CLIC2- Name
- CLIC family member 2
- Type
- protein-coding
- Chromosome
- X
- Position
- 155,272,944–155,334,824 (−)
- Aliases
- CLCNL2, CLIC2b, MRXS32, XAP121
- Ensembl
- ENSG00000155962
- RefSeq RNA
- NM_001289.6
- RefSeq protein
- NP_001280.3
This gene encodes a chloride intracellular channel protein. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. This protein plays a role in inhibiting the function of ryanodine receptor 2. A mutation in this gene is the cause of an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
chloride intracellular channel 2
- Symbol
- CLIC2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr X:155,272,944-155,334,824
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein CLIC2 PDB 2PER.png
Show 7 more facts
- HomoloGene ID
- 48010
- exact match
- identifiers.org/ncbigene/1193
- found in taxon
- Homo sapiens
- chromosome
- human X chromosome
- genomic start
- 154505500
- genomic end
- 154563966
- cytogenetic location
- Xq28
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- See also
- References
- Further reading
- External links
Chloride intracellular channel protein 2 is a protein that in humans is encoded by the CLIC2 gene.
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 2 is a member of the p64 family; the protein is detected in fetal liver and adult skeletal muscle tissue. This gene maps to the candidate region on chromosome X for incontinentia pigmenti.
Excerpted from Wikipedia’s “CLIC2” article, available under the CC BY-SA 4.0 licence.