chlorquinaldol

Also known as 5,7-dichloro-2-methyl-8-hydroxyquinoline, 5,7-dichloro-2-methyl-8-quinolinol, 2-methyl-5,7-dichloro-8-hydroxyquinoline, 5,7-dichloro-8-hydroxy-2-methylquinoline, 5,7-dichloro-8-quinaldinol, 5,7-dichloro-8-hydroxyquinaldine

Chlorquinaldol is an antimicrobial agent and antiseptic. It is a chlorinated derivative of the popular chelating agent 8-hydroxyquinoline. It is applied topically as a cream and internally as a losenge.

Chemical data

Formula: C10H7Cl2NO
Molecular weight: 228.07 g/mol
IUPAC name: 5,7-dichloro-2-methylquinolin-8-ol
SMILES: CC1=NC2=C(C=C1)C(=CC(=C2O)Cl)Cl
InChIKey: GPTXWRGISTZRIO-UHFFFAOYSA-N
XLogP: 3.5
Polar surface area: 33.1 Å²
H-bond donors: 1
H-bond acceptors: 2
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule
Indications: amebiasis

via ChEMBL · EBI

Research

145 papers

Chlorquinaldol Alleviates Lung Fibrosis in Mice by Inhibiting Fibroblast Activation through Targeting Methionine Synthase Reductase.ACS central science · 2024
Chlorquinaldol targets the β-catenin and T-cell factor 4 complex and exerts anti-colorectal cancer activity.Pharmacological research · 2020
Chlorquinaldol, a topical agent for skin and wound infections: anti-biofilm activity and biofilm-related antimicrobial cross-resistance.Infection and drug resistance · 2019
Chlorquinaldol inhibits the activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 inflammasome and ameliorates imiquimod-induced psoriasis-like dermatitis in mice.Chemico-biological interactions · 2022
Antimycotic effect of chlorquinaldol.Transactions of the New York Academy of Sciences · 1955

via PubMed

Wikidata facts

Mass: 226.99

Show 8 more facts

route of administration: intravaginal administration
chemical formula: C₁₀H₇Cl₂NO
canonical SMILES: CC1=NC2=C(C=C1)C(=CC(=C2O)Cl)Cl
World Health Organisation international non-proprietary name: chlorquinaldol
Commons category: Chlorquinaldol
defined daily dose: 0.2
subject has role: bactericide
medical condition treated: vaginitis

Sources (5)

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Encyclopedic overview

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Contents

References

It was marketed by Geigy as an intestinal antiseptic and amebicide with the trade name Siosteran.

Excerpted from Wikipedia’s “chlorquinaldol” article, available under the CC BY-SA 4.0 licence.

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