cholestasis
Sign in to saveAlso known as bile occlusion, obstruction of bile duct
Cholestasis is a condition where the flow of bile from the liver to the duodenum is impaired. The two basic distinctions are:
Key facts
- Medical condition.name
- Cholestasis
- Medical condition.image
- Cholestasis high mag.jpg
- Medical condition.caption
- Micrograph showing bile (yellow) stasis in liver tissue, i.e. cholestasis. H&E stain.
- Medical condition.field
- Gastroenterology
via Wikipedia infobox
Research
47,387 papers- Intrahepatic Cholestasis of Pregnancy.Clinical obstetrics and gynecology · 2020
- Intrahepatic cholestasis of pregnancy.Obstetrics and gynecology · 2014
- [Cholestasis].Vnitrni lekarstvi · 2003
- Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial.The lancet. Gastroenterology & hepatology · 2022
- Neonatal cholestasis.Pediatrics in review · 2004
via PubMed
Wikidata facts
- Image
- Bilirubin pigment in cholestatic liver 40X.jpg
Show 4 more facts
- exact match
- purl.obolibrary.org/obo/HP_0001396
- Commons category
- Cholestasis
- NCI Thesaurus ID
- C83006
- ICD-9-CM
- 576.2
Sources (6)
via Wikidata · CC0
~51 min read
Article
29 sectionsContents
- Signs and symptoms
- Causes
- Drug-induced cholestasis
- Rare causes of cholestasis
- Primary biliary cholangitis
- Primary sclerosing cholangitis
- Familial intrahepatic cholestasis
- Alagille syndrome
- Sepsis
- TPN-based cholestasis
- Intrahepatic cholestasis of pregnancy (obstetric cholestasis)
- Mechanism
- Mechanisms of drug-induced cholestasis
- Diagnosis
- Biomarkers
- Imaging
- Histopathology
- Management
- Surgical management
- Medical management
- Research directions
- Peroxisomes receptor agonists
- Farnesoid X-receptor agonist
- 24-norursodeoxycholic acid
- Immunomodulatory treatments
- Gut microbiome
- See also
- References
- External links
Cholestasis is a condition where the flow of bile from the liver to the duodenum is impaired. The two basic distinctions are: obstructive type of cholestasis, where there is a mechanical blockage in the duct system that can occur from a gallstone or malignancy, and metabolic type of cholestasis, in which there are disturbances in bile formation that can occur because of genetic defects or acquired as a side effect of many medications.
Classification is further divided into acute or chronic and extrahepatic or intrahepatic.