Structure via PubChem · Public domain (PubChem)
cinepazide
Sign in to saveAlso known as cinepazide maleate
Cinepazide or cinepazide maleate (Kelinao or Anjieli in China) is a vasodilator used in China for the treatment of cardiovascular and cerebrovascular diseases, and peripheral vascular diseases. It appears to work by potentiating A2 adenosine receptors.
In the Vinony graph
Within Vinony's link graph, cinepazide is referenced by 187 other articles, and connects out to cerebrovascular disease, International Standard Book Number and Wayback Machine.
It sits within the topics 1-Pyrrolidinyl compounds, Carboxamides and Chemical pages without DrugBank identifier.
Its subject is documented across 5 Wikipedia language editions.
Chemical data
- Formula
- C22H31N3O5
- Molecular weight
- 417.5 g/mol
- IUPAC name
- (E)-1-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
- SMILES
- COC1=CC(=CC(=C1OC)OC)/C=C/C(=O)N2CCN(CC2)CC(=O)N3CCCC3
- InChIKey
- RCUDFXMNPQNBDU-VOTSOKGWSA-N
- XLogP
- 1.5
- Polar surface area
- 71.6 Ų
- H-bond donors
- 0
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1980
- Indications
- cardiovascular disease, Ischemic stroke
via ChEMBL · EBI
Research
57 papers- Cinepazide maleate promotes recovery from spinal cord injury by inhibiting inflammation and prolonging neuronal survival.Drug development research · 2023
- [Effects of cinepazide maleate injection on blood pressure in patients with acute ischemic stroke and hypertension].Zhonghua nei ke za zhi · 2022
- Efficacy analysis of neuroprotective drugs in patients with acute ischemic stroke based on network meta-analysis.Frontiers in pharmacology · 2024
- Efficacy and safety of cinepazide maleate injection in patients with acute ischemic stroke: a multicenter, randomized, double-blind, placebo-controlled trial.BMC neurology · 2020
- Cinepazide maleate protects PC12 cells against oxygen-glucose deprivation-induced injury.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014
via PubMed
Wikidata facts
- Mass
- 417.226
Show 5 more facts
- subject has role
- vasodilator agent
- chemical formula
- C₂₂H₃₁N₃O₅
- canonical SMILES
- COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCN(CC2)CC(=O)N3CCCC3
- isomeric SMILES
- COC1=CC(=CC(=C1OC)OC)/C=C/C(=O)N2CCN(CC2)CC(=O)N3CCCC3
- Commons category
- Cinepazide
Sources (1)
via Wikidata · CC0
~3 min read
Encyclopedic overview
2 sectionsContents
- History
- References
{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 447331147 | IUPAC_name = (2E)-1-{4-[2-Oxo-2-(1-pyrrolidinyl)ethyl]-1-piperazinyl}-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one | image = Cinepazide.svg | image_class = skin-invert-image
| tradename = | pregnancy_AU = | pregnancy_US = | legal_AU = | legal_CA = | legal_UK = | legal_US =
Excerpted from Wikipedia’s “cinepazide” article, available under the CC BY-SA 4.0 licence.