conotoxin

Also known as conotoxins

A conotoxin is one of a group of neurotoxic peptides isolated from the venom of the marine cone snail, genus Conus.

Key facts

Protein family.Pfam: PF05374
Protein family.Symbol: Mu-conotoxin
Protein family.Name: Mu-conotoxin
Protein family.image: PDB 1r9i EBI.jpg
Protein family.caption: nmr solution structure of piiia toxin, nmr, 20 structures
Protein family.InterPro: IPR008036
Protein family.PROSITE: PDOC60004
Protein family.SCOP: 1gib
Protein family.OPM family: 112
Protein family.OPM protein: 1ag7
Protein family.Pfam_clan: CL0083

via Wikipedia infobox

Research

5,290 papers

Conotoxin gene superfamilies.Marine drugs · 2014
Conotoxin Patenting Trends in Academia and Industry.Marine drugs · 2022
In Silico Conotoxin Studies: Progress and Prospects.Molecules (Basel, Switzerland) · 2024
Pathophysiological Responses to Conotoxin Modulation of Voltage-Gated Ion Currents.Marine drugs · 2022
Conotoxin Interactions with α9α10-nAChRs: Is the α9α10-Nicotinic Acetylcholine Receptor an Important Therapeutic Target for Pain Management?Toxins · 2015

via PubMed

~4 min read

Article

9 sections

Contents

Hypervariability
Disulfide connectivities
Types and biological activities
Alpha
Delta, kappa, and omega
Mu
See also
References
External links

A conotoxin is one of a group of neurotoxic peptides isolated from the venom of the marine cone snail, genus Conus.

Conotoxins, which are peptides consisting of 10 to 30 amino acid residues, typically have one or more disulfide bonds. Conotoxins have a variety of mechanisms of actions, most of which have not been determined. However, it appears that many of these peptides modulate the activity of ion channels. Over the last few decades conotoxins have been the subject of pharmacological interest.