vanoxerine

Also known as GBR 12909, GBR12909, 1-{2-[bis(p-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine

Vanoxerine is an investigational drug which is being evaluated for the treatment of heart arrhythmias and cocaine dependence. Vanoxerine is a piperazine derivative which has multiple pharmacological activities including acting as an dopamine reuptake inhibitor, serotonin transporter inhibitor, and as a blocker of the cardiac hERG repolarizing potassium channel (IKr).

In the Vinony graph

Vinony's link graph records 1,454 inbound references to vanoxerine, and connects out to valproic acid, conotoxin and heart arrhythmia.

Vinony files it under 1-(2-(Bis(4-fluorophenyl)methoxy)ethyl)piperazines, 4-Fluorophenyl compounds and Chemical articles with multiple CAS registry numbers.

Vinony links it to 5 Wikipedia language editions.

Chemical data

Formula: C28H32F2N2O
Molecular weight: 450.6 g/mol
IUPAC name: 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine
SMILES: C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
InChIKey: NAUWTFJOPJWYOT-UHFFFAOYSA-N
XLogP: 5.6
Polar surface area: 15.7 Å²
H-bond donors: 0
H-bond acceptors: 5
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 3
Molecule type: Small molecule
Indications: atrial fibrillation, atrial flutter, cocaine dependence, cocaine abuse

via ChEMBL · EBI

Research

530 papers

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 450.24827

Show 5 more facts

chemical formula: C₂₈H₃₂F₂N₂O
canonical SMILES: C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
World Health Organisation international non-proprietary name: vanoxerine
subject has role: dopamine reuptake inhibitor
Commons category: Vanoxerine

Sources (2)

via Wikidata · CC0

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