Structure via PubChem · Public domain (PubChem)
ispronicline
Sign in to saveAlso known as AZD3480, TC 1734, RJR 1734
Ispronicline (TC-1734, AZD-3480) is an experimental drug which acts as a partial agonist at neural nicotinic acetylcholine receptors. It progressed to phase II clinical trials for the treatment of dementia and Alzheimer's disease, but is no longer under development.
In the Vinony graph
Within Vinony's link graph, ispronicline is referenced by 779 other articles, and connects out to Anatomical Therapeutic Chemical Classification System, nicotinic acetylcholine receptor and indopan.
Vinony files it under Alkene derivatives, Chemical pages without DrugBank identifier and Disubstituted pyridines.
Its subject is documented across 4 Wikipedia language editions.
Chemical data
- Formula
- C14H22N2O
- Molecular weight
- 234.34 g/mol
- IUPAC name
- (E,2S)-N-methyl-5-(5-propan-2-yloxy-3-pyridinyl)pent-4-en-2-amine
- SMILES
- C[C@@H](C/C=C/C1=CC(=CN=C1)OC(C)C)NC
- InChIKey
- RPCVIAXDAUMJJP-PZBABLGHSA-N
- XLogP
- 2.5
- Polar surface area
- 34.2 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- attention deficit hyperactivity disorder, memory impairment, Alzheimer disease, schizophrenia
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 234.173
Show 5 more facts
- chemical formula
- C₁₄H₂₂N₂O
- canonical SMILES
- CC(C)OC1=CN=CC(=C1)C=CCC(C)NC
- isomeric SMILES
- C[C@@H](C/C=C/C1=CC(=CN=C1)OC(C)C)NC
- Commons category
- Ispronicline
- subject has role
- nootropic
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Ispronicline (TC-1734, AZD-3480) is an experimental drug which acts as a partial agonist at neural nicotinic acetylcholine receptors. It progressed to phase II clinical trials for the treatment of dementia and Alzheimer's disease, but is no longer under development.
It has also progressed to phase II as a potential treatment for ADHD. With dosages of 50 mg/day showing a significant improvement in ADHD symptoms
Excerpted from Wikipedia’s “ispronicline” article, available under the CC BY-SA 4.0 licence.