memantine

Also known as 3,5-dimethyl-1-adamantanamine, 1,3-dimethyl-5-adamantanamine, 3,5-dimethyl-1-aminoadamantane, 3,5-dimethyltricyclo[3.3.1.1(3,7)]decan-1-amine, 1-amino-3,5-dimethyladamantane, 1,3-dimethylaminoadamantane

Memantine, sold under the brand name Namenda among others, is a medication used to slow the progression of moderate-to-severe Alzheimer's disease. It is taken by mouth.

Chemical data

Formula: C12H21N
Molecular weight: 179.3 g/mol
IUPAC name: 3,5-dimethyladamantan-1-amine
SMILES: CC12CC3CC(C1)(CC(C3)(C2)N)C
InChIKey: BUGYDGFZZOZRHP-UHFFFAOYSA-N
XLogP: 3.3
Polar surface area: 26 Å²
H-bond donors: 1
H-bond acceptors: 1
Formal charge: 0

via PubChem

Research

5,145 papers

Mechanism of action of memantine.Current opinion in pharmacology · 2006
Cholinesterase inhibitors and memantine for the treatment of Alzheimer and non-Alzheimer dementias.Ideggyogyaszati szemle · 2021
Memantine.Drugs & aging · 2003
Memantine: Updating a rare success story in pro-cognitive therapeutics.Neuropharmacology · 2024
Memantine Derivatives as Multitarget Agents in Alzheimer's Disease.Molecules (Basel, Switzerland) · 2020

via PubMed

Described at

Memantine: a medicine to treat some types of dementia. - NHS

NHS medicines information on memantine – what it's used for, side effects, dosage and who can take it.

nhs.uk →

Link to a page describing this subject · 2,355 chars · not written by Vinony

Wikidata facts

Mass: 179.1674

Show 6 more facts

Commons category: Memantine
chemical formula: C₁₂H₂₁N
canonical SMILES: CC12CC3CC(C1)(CC(C3)(C2)N)C
World Health Organisation international non-proprietary name: memantine
defined daily dose: 40
described at URL: www.healthline.com/health/drugs/memantine-oral-tablet

Sources (7)

via Wikidata · CC0

~19 min read

Article

31 sections

Contents

Medical uses
Alzheimer's disease and dementia
Radiation therapy
Adverse effects
Pharmacology
Pharmacodynamics
Glutamatergic
Serotonergic
Cholinergic
Dopaminergic
Sigmaergic
Other actions
Pharmacokinetics
Absorption
Distribution
Metabolism
Elimination
Chemistry
History
Society and culture
Recreational use
Brand names
Research
Psychiatric disorders
Parkinson's disease
Apathy
Long COVID
Catatonia
Autism spectrum disorder
References
Further reading

Memantine, sold under the brand name Namenda among others, is a medication used to slow the progression of moderate-to-severe Alzheimer's disease. It is taken by mouth.

Common side effects include headache, constipation, sleepiness, and dizziness. Severe side effects may include blood clots, psychosis, and heart failure. It is believed to work by acting on NMDA receptors, working as a pore blocker of these ion channels.