Epiboxidine
Sign in to saveEpiboxidine is a chemical compound which acts as a partial agonist at neural nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. It was developed as a less toxic analogue of the potent frog-derived alkaloid epibatidine, which is around 200 times stronger than morphine as an analgesic but is deadly toxic.
Wikidata facts
- Mass
- 178.110613
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- chemical formula
- C₁₀H₁₄N₂O
- isomeric SMILES
- CC1=NOC(=C1)[C@H]2C[C@@H]3CC[C@H]2N3
- canonical SMILES
- CC1=NOC(=C1)C2CC3CCC2N3
- Commons category
- Epiboxidine
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Epiboxidine is a chemical compound which acts as a partial agonist at neural nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. It was developed as a less toxic analogue of the potent frog-derived alkaloid epibatidine, which is around 200 times stronger than morphine as an analgesic but is deadly toxic.
Epiboxidine is around one-tenth as potent as epibatidine as an α4β2 agonist, but has around the same potency as an α3β4 agonist. It has only one-tenth of the analgesic power of epibatidine, but is also much less toxic.