Epiboxidine
Sign in to saveEpiboxidine is a chemical compound which acts as a partial agonist at neural nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. It was developed as a less toxic analogue of the potent frog-derived alkaloid epibatidine, which is around 200 times stronger than morphine as an analgesic but is deadly toxic.
In the Vinony graph
Within Vinony's link graph, Epiboxidine is referenced by 777 other articles, and connects out to choline, nicotinic acetylcholine receptor and allosteric modulator.
It sits within the topics Analgesics, Chemical pages without DrugBank identifier and Drugs missing an ATC code.
Its subject is documented across 4 Wikipedia language editions.
Wikidata facts
- Mass
- 178.110613
Show 4 more facts
- chemical formula
- C₁₀H₁₄N₂O
- isomeric SMILES
- CC1=NOC(=C1)[C@H]2C[C@@H]3CC[C@H]2N3
- canonical SMILES
- CC1=NOC(=C1)C2CC3CCC2N3
- Commons category
- Epiboxidine
Sources (2)
via Wikidata · CC0
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Encyclopedic overview
3 sectionsContents
- Uses
- See also
- References
Epiboxidine is a chemical compound which acts as a partial agonist at neural nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. It was developed as a less toxic analogue of the potent frog-derived alkaloid epibatidine, which is around 200 times stronger than morphine as an analgesic but is deadly toxic.
Epiboxidine is around one-tenth as potent as epibatidine as an α4β2 agonist, but has around the same potency as an α3β4 agonist. It has only one-tenth of the analgesic power of epibatidine, but is also much less toxic.
Excerpted from Wikipedia’s “Epiboxidine” article, available under the CC BY-SA 4.0 licence.