Structure via PubChem · Public domain (PubChem)
copanlisib
Sign in to saveAlso known as BAY 80-6946, BAY80-6946
Copanlisib, sold under the brand name Aliqopa, is a medication used for the treatment of adults experiencing relapsed follicular lymphoma who have received at least two prior systemic therapies.
Chemical data
- Formula
- C23H28N8O4
- Molecular weight
- 480.5 g/mol
- IUPAC name
- 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide
- SMILES
- COC1=C(C=CC2=C1N=C(N3C2=NCC3)NC(=O)C4=CN=C(N=C4)N)OCCCN5CCOCC5
- InChIKey
- PZBCKZWLPGJMAO-UHFFFAOYSA-N
- XLogP
- -0.3
- Polar surface area
- 140 Ų
- H-bond donors
- 2
- H-bond acceptors
- 10
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2017
- Admin. routes
- parenteral
- Indications
- Mantle cell lymphoma, non-Hodgkins lymphoma, diffuse large B-cell lymphoma, neoplasm
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 480.223
- Has use
- medication
Show 3 more facts
- canonical SMILES
- COC1=C(C=CC2=C1N=C(N3C2=NCC3)NC(=O)C4=CN=C(N=C4)N)OCCCN5CCOCC5
- chemical formula
- C₂₃H₂₈N₈O₄
- Commons category
- Duvelisib
via Wikidata · CC0
~3 min read
Encyclopedic overview
8 sectionsContents
- Adverse effects
- Mechanism of action
- History
- Clinical trials
- Society and culture
- Legal status
- References
- Further reading
Copanlisib, sold under the brand name Aliqopa, is a medication used for the treatment of adults experiencing relapsed follicular lymphoma who have received at least two prior systemic therapies.
In November 2023, Bayer announced that it was withdrawing copanlisib from the US market.
Excerpted from Wikipedia’s “copanlisib” article, available under the CC BY-SA 4.0 licence.