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corticotropin

File:Pro-opiomelanocortin.png · Wikimedia Commons · See Wikimedia Commons

MedicationQ185690· pop 55· linked from 477 articles

corticotropin

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Also known as ACTH, Acthar, Purified Cortrophin Gel, H.P. Acthar Gel, Cortigel, Cortrophin, POMC(138-176), adrenomone

hormone

OverviewAI-generated

Corticotropin is a compound classified under the ATC code ACTH. It is available in several dose forms, including Injectable Solution, Injectable Suspension, and Prefilled Syringe. The substance is marketed under the brand names Acthar and Cortrophin. One formulation contains corticotropin combined with zinc hydroxide.

In the United States, corticotropin is also found in the over-the-counter product Adrenal Liquescence, manufactured by Professional Complementary Health Formulas. This specific product, known as Adrenal Liquescence 3001, is an oral preparation. It contains substances such as Glycyrrhiza Glabra, Bee Pollen, Paullinia Cupana Seed, Rosa Canina Fruit, and Asian Ginseng. The product is categorized as a Non-Standardized Food Allergenic Extract and a Non-Standardized Plant Allergenic Extract.

Clinical research involving corticotropin is documented in 160 entries on ClinicalTrials.gov. The term appears in 71,203 PubMed records. The subject is referenced by 477 other encyclopedia articles.

Synthesized by Vinony from 18 facts across 6 sources: Wikidata, PubMed, ClinicalTrials.gov, Rxnorm, Openfda, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.

Medication

Generic name
Adrenal Liquescence
Brand names
Adrenal Liquescence 3001, Acthar, Cortrophin
Drug class
Non-Standardized Food Allergenic Extract, Non-Standardized Plant Allergenic Extract, Adrenocorticotropic Hormone, alpha-Adrenergic Agonist, beta-Adrenergic Agonist
Active ingredients
corticotropin, corticotropin / zinc hydroxide
Route
Oral
Dosage form
Injectable Solution, Injectable Suspension, Prefilled Syringe
Type
Human Otc Drug
Manufacturer
Professional Complementary Health Formulas

Indications: INDICATIONS For the temporary relief of lethargy, lack of energy, sadness, anxiousness, or decreased ability to handle stress.* (per FDA label)

Sources: openFDA · RxNorm (NLM). Not medical advice.

Research

71,203 papers

via PubMed

Clinical Trials

160 registered

via ClinicalTrials.gov

~9 min read

Encyclopedic overview

Adrenocorticotropic hormone (ACTH; also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland. It is also used as a medication and diagnostic agent. ACTH is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress (along with its precursor corticotropin-releasing hormone from the hypothalamus). Its principal effects are increased production and release of cortisol and androgens by the zona fasciculata and zona reticularis, respectively. ACTH is also related to the circadian rhythm in many organisms.

Deficiency of ACTH is an indicator of secondary adrenal insufficiency (suppressed production of ACTH due to an impairment of the pituitary gland or hypothalamus, cf. hypopituitarism) or tertiary adrenal insufficiency (disease of the hypothalamus, with a decrease in the release of corticotropin releasing hormone (CRH)). Conversely, chronically elevated ACTH levels occur in primary adrenal insufficiency (e.g. Addison's disease) when adrenal gland production of cortisol is chronically deficient. In Cushing's disease, a pituitary tumor leads to excessive production of ACTH, which stimulates the adrenal cortex to produce high levels of cortisol.

Excerpted from Wikipedia’s “corticotropin” article, available under the CC BY-SA 4.0 licence.

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