File:Pro-opiomelanocortin.png · Wikimedia Commons · See Wikimedia Commons
corticotropin
Sign in to saveAlso known as ACTH, Acthar, Purified Cortrophin Gel, H.P. Acthar Gel, Cortigel, Cortrophin, POMC(138-176), adrenomone
hormone
Corticotropin is a hormone your body produces that signals your adrenal glands to release cortisol, another important hormone that helps you manage stress and maintain normal body functions. It matters because without corticotropin, your body couldn't properly regulate cortisol levels, which would affect how you handle stress, your energy levels, and various other vital processes.
AI-generated from the Wikipedia summary — may contain errors.
Research
71,203 papers- Corticotropin-releasing factor.ReviewEndocrine reviews · 1982Yasuda N, Greer MA, Aizawa TDOI: 10.1210/edrv-3-2-123
- Corticotropin receptors.ReviewAnnals of the New York Academy of Sciences · 1987Ramachandran J, Tsubokawa M, Gohil KDOI: 10.1111/j.1749-6632.1987.tb24977.x
- Repository corticotropin injection in multiple sclerosis: an update.ReviewNeurodegenerative disease management · 2018Kutz CF, Dix ALDOI: 10.2217/nmt-2018-0008
- The Hypothalamic-Pituitary-Adrenal Axis: A Brief History.ReviewHormone research in paediatrics · 2018Miller WLDOI: 10.1159/000487755
- Corticotropin-releasing hormone: clinical applications.ReviewAnnual review of medicine · 1989Nieman LK, Loriaux DLDOI: 10.1146/annurev.me.40.020189.001555
- Corticotropin releasing factor receptors: characterization and actions in the anterior pituitary gland.ReviewAdvances in experimental medicine and biology · 1988Aguilera G, Abou Samra AB, Harwood JP et al.DOI: 10.1007/978-1-4899-2064-5_7
- [Corticotropin-releasing hormone (CRH)].ReviewNihon rinsho. Japanese journal of clinical medicine · 2005Nasushita R
- Tissue corticotropin releasing factors.ReviewFederation proceedings · 1977Brodish A
via PubMed
Clinical Trials
160 registered- PHASE4UNKNOWNProtocol for H.P. Acthar Gel in Moderately to Severely Active Psoriatic ArthritisFiechtner, Justus J., M.D., P.C. · NCT01939132
- PHASE2COMPLETEDStudy of Efficacy and Safety of Osilodrostat in Cushing's SyndromeNovartis Pharmaceuticals · NCT02468193
- COMPLETEDStress, Hypothalamic-pituitary-adrenal (HPA) Dysfunction, and Relapse in AlcoholismUniversity of Texas Southwestern Medical Center · NCT00744588
- PHASE2COMPLETEDACTH as A Re-emerging theRapy for Uveitis (The ACTHAR Study)Quan Dong Nguyen · NCT02931175
- PHASE4ENROLLING_BY_INVITATIONCombination Osilodrostat and Cabergoline in Cushing's DiseaseUniversity of Basrah · NCT07603466
- PHASE4TERMINATEDTreatment of Chronic Antibody-mediated Rejection in Kidney Transplant With ActharUniversity of Maryland, Baltimore · NCT02546492
Wikidata facts
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- short name
- ACTH
- NCI Thesaurus ID
- C212
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Article
Adrenocorticotropic hormone (ACTH; also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland. It is also used as a medication and diagnostic agent. ACTH is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress (along with its precursor corticotropin-releasing hormone from the hypothalamus). Its principal effects are increased production and release of cortisol and androgens by the zona fasciculata and zona reticularis, respectively. ACTH is also related to the circadian rhythm in many organisms.
Deficiency of ACTH is an indicator of secondary adrenal insufficiency (suppressed production of ACTH due to an impairment of the pituitary gland or hypothalamus, cf. hypopituitarism) or tertiary adrenal insufficiency (disease of the hypothalamus, with a decrease in the release of corticotropin releasing hormone (CRH)). Conversely, chronically elevated ACTH levels occur in primary adrenal insufficiency (e.g. Addison's disease) when adrenal gland production of cortisol is chronically deficient. In Cushing's disease, a pituitary tumor leads to excessive production of ACTH, which stimulates the adrenal cortex to produce high levels of cortisol.