File:Aldosterone-2D-skeletal.svg · Wikimedia Commons · See Wikimedia Commons
aldosterone
Sign in to saveAlso known as (11beta)-11,21-dihydroxy-3,20-dioxopregn-4-en-18-al, (+)-aldosterone, delta-Aldosterone, 18-Formyl-11beta,21-dihydroxy-4-pregnene-3,20-dione, Aldocorten, Reichstein X, 11-Hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-13-carbaldehyde, 18-Oxocorticosterone
Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. It is essential for sodium conservation in the kidney, salivary glands, sweat glands, and colon. It plays a central role in the homeostatic regulation of blood pressure, plasma sodium (Na+), and potassium (K+) levels. It does so primarily by acting on the mineralocorticoid receptors in the distal tubules and collecting ducts of the nephron. It influences the reabsorption of sodium and excretion of potassium (from and into the tubular fluids, respectively) of th
Aldosterone is a hormone produced by your adrenal glands that helps your kidneys control how much sodium and potassium your body retains or removes through urine. It's essential for maintaining your blood pressure and the proper balance of these important minerals in your blood.
AI-generated from the Wikipedia summary — may contain errors.
Chemical data
- Formula
- C21H28O5
- Molecular weight
- 360.4 g/mol
- IUPAC name
- (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde
- SMILES
- C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C=O)O
- InChIKey
- PQSUYGKTWSAVDQ-ZVIOFETBSA-N
- XLogP
- 1.1
- Polar surface area
- 91.7 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
56,813 papers- Primary Aldosteronism, Aldosterone, and Extracellular Vesicles.ReviewEndocrinology · 2022Carvajal CA, Tapia-Castillo A, Pérez JA et al.DOI: 10.1210/endocr/bqab240
- Diagnosis and treatment of primary aldosteronism.ReviewThe lancet. Diabetes & endocrinology · 2021Reincke M, Bancos I, Mulatero P et al.DOI: 10.1016/S2213-8587(21)00210-2
- Aldosterone to Renin Ratio as Screening Tool in Primary Aldosteronism.ReviewExperimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2019Schilbach K, Junnila RK, Bidlingmaier MDOI: 10.1055/a-0672-0836
- Overview of aldosterone-related genetic syndromes and recent advances.ReviewCurrent opinion in endocrinology, diabetes, and obesity · 2018Zennaro MC, Fernandes-Rosa FL, Boulkroun SDOI: 10.1097/MED.0000000000000409
- Aldosterone-Producing Adenomas.Vitamins and hormones · 2019Hellman P, Björklund P, Åkerström TDOI: 10.1016/bs.vh.2018.10.007
- Primary aldosteronism - a multidimensional syndrome.ReviewNature reviews. Endocrinology · 2022Turcu AF, Yang J, Vaidya ADOI: 10.1038/s41574-022-00730-2
- Aldosterone and aldosteronism.ReviewSteroids · 2003Horton RDOI: 10.1016/j.steroids.2003.09.006
- Aldosterone receptor antagonists: current perspectives and therapies.ReviewVascular health and risk management · 2013Guichard JL, Clark D 3rd, Calhoun DA et al.DOI: 10.2147/VHRM.S33759
via PubMed
Wikidata facts
- Mass
- 360.194
Show 4 more facts
- chemical formula
- C₂₁H₂₈O₅
- canonical SMILES
- CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C=O)O
- isomeric SMILES
- C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C=O)O
- Commons category
- Aldosterone
Sources (8)
via Wikidata · CC0
~15 min read
Article
19 sectionsContents
- Biosynthesis
- Stimulation
- Biological function
- Mineralocorticoid receptors
- Control of aldosterone release from the adrenal cortex
- Major regulators
- The role of the [[renin–angiotensin system]]
- The plasma concentration of [[potassium]]
- Adrenocorticotropic hormone
- Miscellaneous regulators
- The role of [[sympathetic nerves]]
- The role of baroreceptors
- The plasma concentration of [[sodium]]
- Aldosterone feedback
- Associated clinical conditions
- Hyperaldosteronism
- Hypoaldosteronism
- Additional images
- References
Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. It is essential for sodium conservation in the kidney, salivary glands, sweat glands, and colon. It plays a central role in the homeostatic regulation of blood pressure, plasma sodium (Na+), and potassium (K+) levels. It does so primarily by acting on the mineralocorticoid receptors in the distal tubules and collecting ducts of the nephron. It influences the reabsorption of sodium and excretion of potassium (from and into the tubular fluids, respectively) of the kidney, thereby indirectly influencing water retention or loss, blood pressure, and blood volume. When dysregulated, aldosterone is pathogenic and contributes to the development and progression of cardiovascular and kidney disease. Aldosterone has exactly the opposite function of the atrial natriuretic hormone secreted by the heart.
Aldosterone is part of the renin–angiotensin–aldosterone system. It has a plasma half-life of less than 20 minutes. Drugs that interfere with the secretion or action of aldosterone are in use as antihypertensives, like lisinopril, which lowers blood pressure by blocking the angiotensin-converting enzyme (ACE), leading to lower aldosterone secretion. The net effect of these drugs is to reduce sodium and water retention but increase the retention of potassium. In other words, these drugs stimulate the excretion of sodium and water in urine, while they block the excretion of potassium.