CREB3L1

Also known as OASIS, cAMP responsive element binding protein 3-like 1, cAMP responsive element binding protein 3 like 1, OI16

CAMP responsive element binding protein 3 like 1, also known as OASIS, is a responsive element binding protein that in humans is encoded by the CREB3L1 gene.

Gene data

CREB3L1

Name: cAMP responsive element binding protein 3 like 1
Type: protein-coding
Position: 46,277,636–46,321,422 (+)
Aliases: C16DELp11.2, DEL16p11.2, OASIS, OI16
Ensembl: ENSG00000157613
RefSeq RNA: NM_001425266.1, NM_001425267.1, NM_001425268.1, NM_001425269.1, NM_052854.4
RefSeq protein: NP_001412195.1, NP_001412196.1, NP_001412197.1, NP_001412198.1, NP_443086.1

The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II osteoblast differentiation regulation of DNA-templated transcription regulation of transcription by RNA polymerase II negative regulation of gene expression endoplasmic reticulum unfolded protein response positive regulation of collagen biosynthetic process response to endoplasmic reticulum stress

Molecular function

transcription cis-regulatory region binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific chromatin binding DNA-binding transcription factor activity protein binding

Cellular component

chromatin chromatin nucleus nucleus nucleus nucleus nucleus endoplasmic reticulum

Pathways

cGMP-PKG signaling pathway - Homo sapiens (human)cAMP signaling pathway - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)AMPK signaling pathway - Homo sapiens (human)Longevity regulating pathway - Homo sapiens (human)Adrenergic signaling in cardiomyocytes - Homo sapiens (human)TNF signaling pathway - Homo sapiens (human)Thermogenesis - Homo sapiens (human)Cholinergic synapse - Homo sapiens (human)Dopaminergic synapse - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

cAMP responsive element binding protein 3 like 1

Symbol: CREB3L1
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:46,277,636-46,321,422
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 8058
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/90993
chromosome: human chromosome 11
genomic start: 46277662
genomic end: 46321409
cytogenetic location: 11p11.2
expressed in: rectum

Sources (3)

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Encyclopedic overview

4 sections

Contents

Function
Implications in Disease
References
Further reading

CAMP responsive element binding protein 3 like 1, also known as OASIS, is a responsive element binding protein that in humans is encoded by the CREB3L1 gene.

== Function == The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved, and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013].

Excerpted from Wikipedia’s “CREB3L1” article, available under the CC BY-SA 4.0 licence.

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