cAMP response element binding protein
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alt=|thumb|200x200px|CREB (top) is a transcription factor capable of binding [[DNA (bottom) and regulating gene expression.]] CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene.
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Vinony's link graph records 1,016 inbound references to cAMP response element binding protein, and connects out to homeobox, Fos proto-oncogene, AP-1 transcription factor subunit and ATF1.
Vinony files it under Addiction and Transcription factors.
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Wikidata facts
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- CREB
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Encyclopedic overview
9 sectionsContents
- Subtypes
- Structure
- Mechanism of action
- Function in the brain
- Disease linkage
- Involvement in circadian rhythms
- Discovery of CREB involvement in circadian rhythms
- References
- External links
alt=|thumb|200x200px|CREB (top) is a transcription factor capable of binding [[DNA (bottom) and regulating gene expression.]] CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene.
Genes whose transcription is regulated by CREB include: c-fos, BDNF, tyrosine hydroxylase, numerous neuropeptides (such as somatostatin, enkephalin, VGF, corticotropin-releasing hormone), and genes involved in the mammalian circadian clock (PER1, PER2).
Excerpted from Wikipedia’s “cAMP response element binding protein” article, available under the CC BY-SA 4.0 licence.