Structure via PubChem · Public domain (PubChem)
cyclofenil
Sign in to saveAlso known as Sexovid, [4-[(4-Acetoxyphenyl)-cyclohexylidene-methyl]phenyl] acetate, F-6066, bis(p-acetoxyphenyl)-cyclohexylidenemethane, ICI-48213, H-3452
Cyclofenil, sold under the brand name Sexovid among others, is a selective estrogen receptor modulator (SERM) medication which is used as a gonadotropin stimulant or ovulation inducer and in menopausal hormone therapy in women. It is mostly no longer available. The medication is taken by mouth.
Chemical data
- Formula
- C23H24O4
- Molecular weight
- 364.4 g/mol
- IUPAC name
- [4-[(4-acetyloxyphenyl)-cyclohexylidenemethyl]phenyl] acetate
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
218 papers- An estrogen antagonist, cyclofenil, has anti-dengue-virus activity.Archives of virology · 2019
- Cyclofenil for Raynaud's phenomenon in progressive systemic sclerosis.The Cochrane database of systematic reviews · 2000
- [Cyclofenil in gynecologic practice].Revue francaise de gynecologie et d'obstetrique · 1972
- [Ovulation induction with cyclofenil].Ginecologia y obstetricia de Mexico · 1977
- Development of bivalent triarylalkene- and cyclofenil-derived dual estrogen receptor antagonists and downregulators.European journal of medicinal chemistry · 2020
via PubMed
Wikidata facts
- Mass
- 364.167
Show 2 more facts
- chemical formula
- C₂₃H₂₄O₄
- canonical SMILES
- CC(=O)OC1=CC=C(C=C1)C(=C2CCCCC2)C3=CC=C(C=C3)OC(=O)C
Sources (2)
via Wikidata · CC0
~4 min read
Article
17 sectionsContents
- Medical use
- Available forms
- Non-medical use
- Contraindications
- Side effects
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- History
- Society and culture
- Generic names
- Brand names
- Availability
- Regulation
- Research
- References
Cyclofenil, sold under the brand name Sexovid among others, is a selective estrogen receptor modulator (SERM) medication which is used as a gonadotropin stimulant or ovulation inducer and in menopausal hormone therapy in women. It is mostly no longer available. The medication is taken by mouth.
Side effects of cyclofenil include liver toxicity among others. It is a selective estrogen receptor modulator (SERM) and hence is a mixed agonist–antagonist of the estrogen receptor (ER), the biological target of estrogens like estradiol. It has antiestrogenic effects on the hypothalamic–pituitary–gonadal axis and hence can increase sex hormone production and stimulate ovulation.
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via Wikidata sitelinks · CC0