Structure via PubChem · Public domain (PubChem)
desflurane
Sign in to saveAlso known as I-653, Suprane®, 1,1,1,2-tetrafluoro-2-(difluoromethoxy)ethane, Suprane, (+-)-2-difluoromethyl 1,2,2,2-tetrafluoroethyl ether, difluoromethyl 1,2,2,2-tetrafluoroethyl ether, Desflurano, 1,1,1,2-Tetrafluoro-2-(difluoromethoxy)ethane
Desflurane (1,2,2,2-tetrafluoroethyl difluoromethyl ether), under the brand name Suprane, is a highly fluorinated methyl ethyl ether used for induction and maintenance of general anesthesia. Desflurane was developed in the 1980s and approved by the FDA in 1992 as a faster acting and clearing inhalant anesthetic compared to previously used inhalant anesthetics. Like halothane, enflurane, and isoflurane, it is a racemic mixture of (R) and (S) optical isomers (enantiomers). It has the most rapid onset and offset of the volatile anesthetic drugs used for general anesthesia due to its low solubilit
Chemical data
- Formula
- C3H2F6O
- Molecular weight
- 168.04 g/mol
- IUPAC name
- 2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane
- SMILES
- C(C(F)(F)F)(OC(F)F)F
- InChIKey
- DPYMFVXJLLWWEU-UHFFFAOYSA-N
- XLogP
- 2.6
- Polar surface area
- 9.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Research
2,976 papers- Desflurane decommissioning: more than meets the eye.Anaesthesia · 2024
- Myocardial Protection by Desflurane: From Basic Mechanisms to Clinical Applications.Journal of cardiovascular pharmacology · 2023
- Desflurane clinical pharmacokinetics and pharmacodynamics.Clinical pharmacokinetics · 1994
- Desflurane versus propofol for general anesthesia maintenance in obese patients: A pilot meta-analysis.Journal of clinical anesthesia · 2021
- Desflurane Should Not Des-appear.Anesthesia and analgesia · 2021
via PubMed
Wikidata facts
- Mass
- 168.000984
Show 4 more facts
- chemical formula
- C₃H₂F₆O
- canonical SMILES
- C(C(F)(F)F)(OC(F)F)F
- Commons category
- Desflurane
- global warming potential
- 2143
via Wikidata · CC0
~10 min read
Article
10 sectionsContents
- Medical uses
- Adverse effects
- Contraindications
- Pharmacology
- Chemistry
- Stereochemistry
- Physical properties
- Global-warming potential
- References
- Further reading
Desflurane (1,2,2,2-tetrafluoroethyl difluoromethyl ether), under the brand name Suprane, is a highly fluorinated methyl ethyl ether used for induction and maintenance of general anesthesia. Desflurane was developed in the 1980s and approved by the FDA in 1992 as a faster acting and clearing inhalant anesthetic compared to previously used inhalant anesthetics. Like halothane, enflurane, and isoflurane, it is a racemic mixture of (R) and (S) optical isomers (enantiomers). It has the most rapid onset and offset of the volatile anesthetic drugs used for general anesthesia due to its low solubility in blood. It is lipophobic and hydrophobic, and therefore does not easily dissolve in blood.
Some drawbacks of desflurane are its low potency, its pungency, and its high cost (though at low flow fresh gas rates, the cost difference between desflurane and isoflurane appears to be insignificant). It may cause tachycardia and airway irritability when administered at concentrations greater than 10% by volume. Due to this airway irritability, desflurane is infrequently used to induce anesthesia via inhalation techniques.