dexmethylphenidate
Sign in to saveAlso known as FOC124, D-TMP, d-threo-methylphenidate, (+)-threo-methylphenidate, methyl (R)-phenyl[(R)-piperidin-2-yl]acetate
Dexmethylphenidate, sold under the brand name Focalin among others, is a central nervous system (CNS) stimulant used in the treatment of attention deficit hyperactivity disorder (ADHD) in those over the age of five years. It is taken by mouth. The immediate-release formulation lasts up to five hours while the extended-release formulation lasts up to twelve hours. It is the more active enantiomer of methylphenidate. Methylphenidate has been shown to be more effective than atomoxetine and superior in treating ADHD symptoms when compared.
Wikidata facts
- Mass
- 233.141579
Show 7 more facts
- Commons category
- Dexmethylphenidate
- name
- dexmethylphenidate
- chemical formula
- C₁₄H₁₉NO₂
- canonical SMILES
- COC(=O)C(C1CCCCN1)C2=CC=CC=C2
- isomeric SMILES
- COC(=O)[C@@H]([C@H]1CCCCN1)C2=CC=CC=C2
- World Health Organisation international non-proprietary name
- dexmethylphenidate
- defined daily dose
- 15.0
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Article
13 sectionsContents
- Medical uses
- Contraindications
- Hypertension
- Cardiac disease
- Glaucoma
- Adverse effects
- Interactions
- Pharmacology
- Pharmacokinetics
- Mechanism of action
- Chemistry
- Notes
- References
Dexmethylphenidate, sold under the brand name Focalin among others, is a central nervous system (CNS) stimulant used in the treatment of attention deficit hyperactivity disorder (ADHD) in those over the age of five years. It is taken by mouth. The immediate-release formulation lasts up to five hours while the extended-release formulation lasts up to twelve hours. It is the more active enantiomer of methylphenidate. Methylphenidate has been shown to be more effective than atomoxetine and superior in treating ADHD symptoms when compared.
Common side effects include abdominal pain, loss of appetite, and fever. Serious side effects may include psychosis, sudden cardiac death, mania, anaphylaxis, seizures, and priapism. Safety during pregnancy and breastfeeding is unclear.