DHH

Name

desert hedgehog signaling molecule

Type

protein-coding

Aliases

GDMN, GDXYM, HHG-3, SRXY7

This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development. [provided by RefSeq, May 2010].

via MyGene.info

Gene · Ensembl

desert hedgehog signaling molecule

Symbol

DHH

Biotype

Protein coding

Organism

Homo sapiens

Location

12:49,086,656-49,094,807

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

Protein DHH PDB 2WFQ.png

via Wikidata · CC0