HHIP

Also known as HIP, hedgehog interacting protein

Hedgehog interacting protein (HHIP) is a protein that in humans is encoded by the HHIP gene.

Gene data

HHIP

Name: hedgehog interacting protein
Type: protein-coding
Position: 144,645,723–144,745,271 (+)
Aliases: HIP
Ensembl: ENSG00000164161
RefSeq RNA: NM_022475.3, XM_005263178.6, XM_006714288.5
RefSeq protein: NP_071920.1, XP_005263235.1, XP_006714351.1

This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.[provided by RefSeq, Feb 2011].

Gene Ontology

Biological process

negative regulation of signal transduction negative regulation of signal transduction negative regulation of smoothened signaling pathway skeletal system morphogenesis skeletal system morphogenesis

Molecular function

protein binding zinc ion binding hedgehog family protein binding

Cellular component

extracellular region cytoplasm plasma membrane plasma membrane cell surface ciliary membrane

Pathways

cAMP signaling pathway - Homo sapiens (human)Hedgehog signaling pathway - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Basal cell carcinoma - Homo sapiens (human)Signal Transduction Signaling by Hedgehog Ligand-receptor interactions Hedgehog 'on' state Hedgehog Signaling Pathway

via MyGene.info

Gene · Ensembl

hedgehog interacting protein

Symbol: HHIP
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:144,645,723-144,745,271
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein HHIP PDB 2WFT.png

Show 7 more facts

HomoloGene ID: 32469
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/64399
genomic end: 145666423
genomic start: 144646156
chromosome: human chromosome 4
cytogenetic location: 4q31.21

Sources (4)

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Encyclopedic overview

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Contents

References
Further reading

Hedgehog interacting protein (HHIP) is a protein that in humans is encoded by the HHIP gene.

This gene encodes a protein similar to the mouse hedgehog interacting protein, a regulatory component of the Hedgehog signaling pathway. Members of the hedgehog family are evolutionarily conserved proteins which are involved in many fundamental processes in embryonic development, including anteroposterior patterns of limbs and regulation of left-right asymmetry.

Excerpted from Wikipedia’s “HHIP” article, available under the CC BY-SA 4.0 licence.