Structure via PubChem · Public domain (PubChem)
didanosine
Sign in to saveAlso known as dideoxyinosine, Videx EC®, 9-((2R,5S)-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one, 2,3-dideoxyinosine, DDI, ddIno, 9-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one, 2′,3′-dideoxyinosine
Didanosine, sold under the brand name Videx among others, is a medication used to treat HIV/AIDS. It is used in combination with other medications as part of highly active antiretroviral therapy (HAART). It is of the reverse-transcriptase inhibitor class.
In the Vinony graph
Within Vinony's link graph, didanosine is referenced by 160 other articles, and connects out to tenofovir alafenamide, antiretroviral therapy for HIV/AIDS and nucleoside analogue.
Vinony files it under Drugboxes which contain changes to watched fields, Drugs developed by Bristol Myers Squibb and ECHA InfoCard ID from Wikidata.
Its subject is documented across 20 Wikipedia language editions.
Key facts
- Drug.NIAID_ChemDB
- 000004
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 458775891
- Drug.image
- Didanosin.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200
- Drug.image2
- Didanosine ball-and-stick model.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Videx, Videx EC
- Drug.MedlinePlus
- a691006
- Drug.pregnancy_AU
- B2
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- J05
- Drug.ATC_suffix
- AF02
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.bioavailability
- 30 to 54%
- Drug.protein_bound
- Less than 5%
via Wikipedia infobox
Chemical data
- Formula
- C10H12N4O3
- Molecular weight
- 236.23 g/mol
- IUPAC name
- 9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
- SMILES
- C1C[C@@H](O[C@@H]1CO)N2C=NC3=C2NC=NC3=O
- InChIKey
- BXZVVICBKDXVGW-NKWVEPMBSA-N
- XLogP
- -1.2
- Polar surface area
- 88.7 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1991
- Admin. routes
- oral
- Indications
- HIV infection, lymphoma, AIDS, AIDS related complex
via ChEMBL · EBI
Research
2,882 papers- Didanosine.The Annals of pharmacotherapy · 1992
- [Didanosine].Enfermedades infecciosas y microbiologia clinica · 1995
- Update on didanosine.Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) · 2002
- Didanosine-induced Retinopathy: New Insights with Long-term Follow-up.Ocular immunology and inflammation · 2022
- Zalcitabine and didanosine.Lancet (London, England) · 1993
via PubMed
Wikidata facts
- Subclass of
- nucleoside analogue
- Mass
- 236.091
- Has use
- medication
Show 10 more facts
- chemical formula
- C₁₀H₁₂N₄O₃
- medical condition treated
- HIV infection
- canonical SMILES
- C1CC(OC1CO)N2C=NC3=C2NC=NC3=O
- isomeric SMILES
- C1C[C@@H](O[C@@H]1CO)N2C=NC3=C2NC=NC3=O
- World Health Organisation international non-proprietary name
- didanosine
- defined daily dose
- 0.4
- subject has role
- antiviral drug
- Commons category
- Didanosine
- legal status (medicine)
- boxed warning
- significant drug interaction
- ribavirin
Sources (6)
via Wikidata · CC0
~5 min read
Encyclopedic overview
8 sectionsContents
- Adverse effects
- Drug interactions
- Resistance
- Mechanism of action
- Pharmacokinetics
- History
- References
- Further reading
Didanosine, sold under the brand name Videx among others, is a medication used to treat HIV/AIDS. It is used in combination with other medications as part of highly active antiretroviral therapy (HAART). It is of the reverse-transcriptase inhibitor class.
Didanosine was first described in 1975 and approved for use in the United States in 1991.
Excerpted from Wikipedia’s “didanosine” article, available under the CC BY-SA 4.0 licence.