DIDS

Also known as 4,4'-diisothiocyanostilbene-2,2'-disulphonic acid, 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid, ABC inhibitor 2, 2,2'-ethene-1,2-diylbis(5-isothiocyanatobenzenesulfonic acid), 4,4'-diisothiocyano-2,2'-stilbenedisulfonic acid, 4,4'-diisothiocyanato-2,2'-stilbenedisulfonic acid

4,4′-Diisothiocyano-2,2′-stilbenedisulfonic acid (DIDS) is an anion exchange inhibitor, blocking reversibly, and later irreversibly, exchangers such as chloride-bicarbonate exchanger.

Research

4,170 papers

DIDS inhibits Vibrio vulnificus cytotoxicity by interfering with TolC-mediated RtxA1 toxin secretion.European journal of pharmacology · 2020
Molecular Determinant of DIDS Analogs Targeting RAD51 Activity.Molecules (Basel, Switzerland) · 2021
DIDS inhibits overexpression BAK1-induced mitochondrial apoptosis through GSK3β/β-catenin signaling pathway.Journal of cellular physiology · 2018
DIDS reduces ischemia/reperfusion-induced myocardial injury in rats.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2015
Synthesis and biological evaluation of DIDS analogues as efficient inhibitors of RAD51 involved in homologous recombination.Bioorganic & medicinal chemistry letters · 2023

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Wikidata facts

Mass: 453.94217

Show 2 more facts

chemical formula: C₁₆H₁₀N₂O₆S₄
canonical SMILES: C1=CC(=C(C=C1N=C=S)S(=O)(=O)O)C=CC2=C(C=C(C=C2)N=C=S)S(=O)(=O)O

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Contents

References

4,4′-Diisothiocyano-2,2′-stilbenedisulfonic acid (DIDS) is an anion exchange inhibitor, blocking reversibly, and later irreversibly, exchangers such as chloride-bicarbonate exchanger.

==References==