Structure via PubChem · Public domain (PubChem)
pranidipine
Sign in to savePranidipine is a calcium channel blocker. It is a long acting calcium channel antagonist of the dihydropyridine group.
Chemical data
- Formula
- C25H24N2O6
- Molecular weight
- 448.5 g/mol
- IUPAC name
- 3-O-methyl 5-O-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- SMILES
- CC1=C(C(C(=C(N1)C)C(=O)OC/C=C/C2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC
- InChIKey
- XTFPDGZNWTZCMF-DHZHZOJOSA-N
- XLogP
- 4.7
- Polar surface area
- 110 Ų
- H-bond donors
- 1
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
40 papers- Pranidipine, a 1,4-dihydropyridine calcium channel blocker that enhances nitric oxide-induced vascular relaxation.Cardiovascular drug reviews · 2001
- Pranidipine enhances the action of nitric oxide released from endothelial cells.Hypertension (Dallas, Tex. : 1979) · 2000
- Effects of pranidipine, a new calcium antagonist, on circulation in the choroid, retina and optic nerve head.Current eye research · 1999
- Pranidipine enhances relaxation produced by endothelium-derived relaxing factor in carotid artery.European journal of pharmacology · 1999
- Comparative effects of pranidipine with amlodipine in rats with heart failure.Pharmacology · 2006
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 448.163
Show 5 more facts
- chemical formula
- C₂₅H₂₄N₂O₆
- isomeric SMILES
- CC1=C(C(C(=C(N1)C)C(=O)OC/C=C/C2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC
- canonical SMILES
- CC1=C(C(C(=C(N1)C)C(=O)OCC=CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC
- subject has role
- calcium channel blocker
- Commons category
- Pranidipine
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Pranidipine is a calcium channel blocker. It is a long acting calcium channel antagonist of the dihydropyridine group.
==References==
Excerpted from Wikipedia’s “pranidipine” article, available under the CC BY-SA 4.0 licence.