Structure via PubChem · Public domain (PubChem)
amiloride
Sign in to saveAlso known as amiloride HCl, Midamor®, N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide, 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide, Amiloridum, Amipramidine, Amilorida
Amiloride, sold under the trade name Midamor among others, is a medication typically used with other medications to treat high blood pressure or swelling due to heart failure or cirrhosis of the liver. Amiloride is classified as a potassium-sparing diuretic. Amiloride is often used together with another diuretic, such as a thiazide or loop diuretic. It is taken by mouth. Onset of action is about two hours and it lasts for about a day.
Chemical data
- Formula
- C6H8ClN7O
- Molecular weight
- 229.63 g/mol
- IUPAC name
- 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
- SMILES
- C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N
- InChIKey
- XSDQTOBWRPYKKA-UHFFFAOYSA-N
- XLogP
- -0.7
- Polar surface area
- 159 Ų
- H-bond donors
- 4
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
12,588 papers- Amiloride: A review.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2020
- Amiloride and calciuria.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022
- Amiloride and its analogs as tools in the study of ion transport.The Journal of membrane biology · 1988
- Amiloride-induced hyponatremia.Acta medica Scandinavica · 1980
- Amiloride and vertebrate gustatory responses to NaCl.Neuroscience and biobehavioral reviews · 1998
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 229.048
- Has use
- medication
Show 10 more facts
- chemical formula
- C₆H₈ClN₇O
- medical condition treated
- nephrogenic diabetes insipidus
- subject has role
- essential medicine
- isomeric SMILES
- C1(=C(N=C(C(=N1)Cl)N)N)/C(=N/C(=N)N)/O
- canonical SMILES
- C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N
- Commons category
- Amiloride
- defined daily dose
- 10
- stylized name
- aMILoride
- significant drug interaction
- valsartan
- World Health Organisation international non-proprietary name
- amiloride
via Wikidata · CC0
~15 min read
Encyclopedic overview
27 sectionsContents
- Medical uses
- Specific populations
- Diabetics
- Poor kidney function
- Lactation
- Pregnancy
- Contraindications
- Adverse effects
- Overdose
- Interactions
- Pharmacology
- Mechanism of action
- Diuresis
- Miscellaneous
- Pharmacokinetics
- Absorption
- Distribution
- Metabolism
- Excretion
- Pharmacogenomics
- Chemistry
- History
- Society and culture
- Formulations and trade names
- Research
- References
- External links
Amiloride, sold under the trade name Midamor among others, is a medication typically used with other medications to treat high blood pressure or swelling due to heart failure or cirrhosis of the liver. Amiloride is classified as a potassium-sparing diuretic. Amiloride is often used together with another diuretic, such as a thiazide or loop diuretic. It is taken by mouth. Onset of action is about two hours and it lasts for about a day.
Common side effects include high blood potassium, vomiting, loss of appetite, rash, and headache. The risk of high blood potassium is greater in those with kidney problems, diabetes, and those who are older. Amiloride blocks the epithelial sodium channel (ENaC) in the late distal tubule, connecting tubule, and collecting duct of the nephron, which both reduces absorption of sodium ion from the lumen of the nephron and reduces excretion of potassium ion into the lumen.
Excerpted from Wikipedia’s “amiloride” article, available under the CC BY-SA 4.0 licence.