valsartan

Also known as VAL489, CGP-48933, N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine, N-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine, (S)-N-valeryl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl}-valine

Valsartan, sold under the brand name Diovan among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. It is an angiotensin II receptor blocker (ARB). It is a reasonable initial treatment for high blood pressure. It is taken by mouth.

Key facts

Drug.verifiedrevid: 470628341
Drug.image: Valsartan skeletal.svg
Drug.image_class: skin-invert-image
Drug.image2: Valsartan-from-xtal-3D-bs-17.png
Drug.image_class2: bg-transparent
Drug.tradename: Diovan, others
Drug.MedlinePlus: a697015
Drug.DailyMedID: Valsartan
Drug.pregnancy_AU: D
Drug.routes_of_administration: By mouth
Drug.class: Angiotensin II receptor antagonist
Drug.ATC_prefix: C09
Drug.ATC_suffix: CA03
Drug.ATC_supplemental: , , , , , , ,
Drug.legal_AU: S4
Drug.legal_UK: POM
Drug.legal_US: Rx-only
Drug.bioavailability: 25%

via Wikipedia infobox

Chemical data

Formula: C24H29N5O3
Molecular weight: 435.5 g/mol
IUPAC name: (2S)-3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid
SMILES: CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)[C@@H](C(C)C)C(=O)O
InChIKey: ACWBQPMHZXGDFX-QFIPXVFZSA-N
XLogP: 4.4
Polar surface area: 112 Å²
H-bond donors: 2
H-bond acceptors: 6
Formal charge: 0

via PubChem

Research

6,778 papers

Sacubitril/Valsartan: Neprilysin Inhibition 5 Years After PARADIGM-HF.JACC. Heart failure · 2020
Valsartan/hydrochlorothiazide.Drugs · 1999
The efficacy and safety of sacubitril/valsartan in chronic kidney disease: a systematic review and meta-analysis.International urology and nephrology · 2024
Valsartan.Profiles of drug substances, excipients, and related methodology · 2015
Efficacy and Safety of Sacubitril/Valsartan Versus Amlodipine in Japanese Patients With Essential Hypertension: A Randomized, Multicenter, Open-Label, Noninferiority Study (PARASOL Study).Journal of clinical hypertension (Greenwich, Conn.) · 2025

via PubMed

Wikidata facts

Mass: 435.22704

Show 6 more facts

chemical formula: C₂₄H₂₉N₅O₃
isomeric SMILES: CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)[C@@H](C(C)C)C(=O)O
canonical SMILES: CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)C(C(C)C)C(=O)O
World Health Organisation international non-proprietary name: valsartan
defined daily dose: 80
Commons category: Valsartan

Sources (10)

via Wikidata · CC0

~14 min read

Article

21 sections

Contents

Medical uses
High blood pressure
Heart failure
Diabetic kidney disease
Contraindications
Side effects
Heart failure
Hypertension
Kidney failure
Interactions
Food interaction
Pharmacology
Pharmacodynamics
Pharmacokinetics
Society and culture
Economics
Combinations
Recalls
Shortages
Research
References

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