Structure via PubChem · Public domain (PubChem)
olmesartan
Sign in to saveAlso known as RNH-6270, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid, 4-(hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid
Olmesartan, sold under the brand name Benicar among others, is a medication used to treat high blood pressure (hypertension). It is taken orally (swallowed by mouth). Versions are available as the combination olmesartan/hydrochlorothiazide and olmesartan/amlodipine. It is available as a prodrug, olmesartan medoxomil.
Key facts
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 462265064
- Drug.image
- Olmesartan.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Benicar
- Drug.MedlinePlus
- a603006
- Drug.DailyMedID
- Olmesartan
- Drug.routes_of_administration
- Oral
- Drug.ATC_prefix
- C09
- Drug.ATC_suffix
- CA08
- Drug.ATC_supplemental
- (with diuretics) (with amlodipine)
- Drug.legal_US
- Rx-only
- Drug.legal_status
- Rx-only
- Drug.bioavailability
- 26%
- Drug.metabolism
- Liver (cannot be removed by hemodialysis)
- Drug.elimination_half life
- 13 hours
- Drug.excretion
- Kidney 40%, bile duct 60%
- Drug.CAS_number
- 144689-63-4
via Wikipedia infobox
Chemical data
- Formula
- C24H26N6O3
- Molecular weight
- 446.5 g/mol
- IUPAC name
- 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid
- SMILES
- CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)O)C(C)(C)O
- InChIKey
- VTRAEEWXHOVJFV-UHFFFAOYSA-N
- XLogP
- 3.2
- Polar surface area
- 130 Ų
- H-bond donors
- 3
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Research
2,008 papers- Olmesartan-induced collagenous gastritis.Lancet (London, England) · 2024
- [Olmesartan-associated Enteropathy].Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae · 2021
- Olmesartan: 360-degree Perspectives Befitting an Angiotensin Receptor Blocker.The Journal of the Association of Physicians of India · 2024
- Efficacy of sacubitril/valsartan versus olmesartan in Japanese patients with essential hypertension: a randomized, double-blind, multicenter study.Hypertension research : official journal of the Japanese Society of Hypertension · 2022
- Olmesartan-associated sprue-like enteropathy.Lancet (London, England) · 2023
via PubMed
~7 min read
Encyclopedic overview
9 sectionsContents
- Medical uses
- Contraindications
- Adverse effects
- Chemistry
- History
- Society and culture
- Brand names
- Research
- References
{{Infobox drug | Verifiedfields = changed | verifiedrevid = 462265064 | image = Olmesartan.svg | image_class = skin-invert-image | width = | alt = | caption =
| pronounce = | tradename = Benicar | Drugs.com = | MedlinePlus = a603006 | DailyMedID = Olmesartan | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = Oral | class = | ATC_prefix = C09 | ATC_suffix = CA08 | ATC_supplemental = (with diuretics) (with amlodipine)
Excerpted from Wikipedia’s “olmesartan” article, available under the CC BY-SA 4.0 licence.