Structure via PubChem · Public domain (PubChem)
quinapril
Sign in to saveAlso known as CI-906, Quinaprilum
Quinapril, sold under the brand name Accupril by the Pfizer corporation, is a medication used to treat high blood pressure (hypertension), heart failure, and diabetic kidney disease. It is a first line treatment for high blood pressure. It is taken by mouth.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 464378463
- Drug.image
- Quinapril structure.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 222
- Drug.USAN
- Quinapril hydrochloride
- Drug.tradename
- Accupril, others
- Drug.MedlinePlus
- a692026
- Drug.DailyMedID
- Quinapril
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- C09
- Drug.ATC_suffix
- AA06
- Drug.legal_US
- Rx-only
- Drug.legal_status
- Rx-only
- Drug.protein_bound
- 97%
- Drug.elimination_half life
- 2 hours
- Drug.CAS_number
- 85441-61-8
- Drug.PubChem
- 54892
via Wikipedia infobox
Chemical data
- Formula
- C25H30N2O5
- Molecular weight
- 438.5 g/mol
- IUPAC name
- (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
- SMILES
- CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CC3=CC=CC=C3C[C@H]2C(=O)O
- InChIKey
- JSDRRTOADPPCHY-HSQYWUDLSA-N
- XLogP
- 1.2
- Polar surface area
- 95.9 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Research
865 papers- Benefit and risk evaluation of quinapril hydrochloride.Expert opinion on drug safety · 2023
- Quinapril: overview of preclinical data.Clinical cardiology · 1990
- Quinapril. A reappraisal of its pharmacology and therapeutic efficacy in cardiovascular disorders.Drugs · 1994
- Quinapril--a preclinical review of the pharmacology, pharmacokinetics, and toxicology.Angiology · 1989
- Quinapril: a further update of its pharmacology and therapeutic use in cardiovascular disorders.Drugs · 2002
via PubMed
Wikidata facts
- Mass
- 438.215472
Show 6 more facts
- chemical formula
- C₂₅H₃₀N₂O₅
- canonical SMILES
- CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3=CC=CC=C3CC2C(=O)O
- isomeric SMILES
- CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CC3=CC=CC=C3C[C@H]2C(=O)O
- World Health Organisation international non-proprietary name
- quinapril
- defined daily dose
- 15
- Commons category
- Quinapril
via Wikidata · CC0
~3 min read
Article
7 sectionsContents
- Medical uses
- Contraindications
- Side effects
- Mechanism of action
- Nitrosamine controversy and voluntary recall
- References
- External links
Quinapril, sold under the brand name Accupril by the Pfizer corporation, is a medication used to treat high blood pressure (hypertension), heart failure, and diabetic kidney disease. It is a first line treatment for high blood pressure. It is taken by mouth.
Common side effects include headaches, dizziness, feeling tired, and cough. Serious side effects may include liver problems, low blood pressure, angioedema, kidney problems, and high blood potassium. Use in pregnancy and breastfeeding is not recommended. It is among a class of drugs called ACE inhibitors and works by decreasing renin-angiotensin-aldosterone system activity.