File:Digoxin.svg · Wikimedia Commons · See Wikimedia Commons
digoxin
Sign in to saveAlso known as Lanoxicaps, Lanoxin, Vanoxin, Lanoxin Pediatric, Digoxin Pediatric, 12beta-Hydroxydigitoxin, Digossina, Lanadicor
Digoxin, sold under the brand name Lanoxin among others, is a medication used to treat various heart conditions. Most frequently it is used for atrial fibrillation, atrial flutter, and heart failure. Digoxin is one of the oldest medications used in the field of cardiology. It works by increasing myocardial contractility, increasing stroke volume and blood pressure, reducing heart rate, and somewhat extending the time frame of the contraction. Digoxin is taken by mouth or by injection into a vein. Digoxin has a half life of approximately 36 hours given at average doses in patients with normal r
Chemical data
- Formula
- C41H64O14
- Molecular weight
- 780.9 g/mol
- IUPAC name
- 3-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-3-[(2R,4S,5S,6R)-5-[(2S,4S,5S,6R)-5-[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one
- SMILES
- C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5C[C@H]([C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)O)C)C)C)O)O
- InChIKey
- LTMHDMANZUZIPE-PUGKRICDSA-N
- XLogP
- 1.3
- Polar surface area
- 203 Ų
- H-bond donors
- 6
- H-bond acceptors
- 14
- Formal charge
- 0
via PubChem
Research
17,680 papers- Expert Consensus on the Diagnosis and Management of Digoxin Toxicity.The American journal of medicine · 2025
- Role of Digoxin in Atrial Fibrillation.Journal of pharmacy practice · 2017
- Digoxin and nifedipine.The American journal of cardiology · 1985
- [Digoxin].Nihon rinsho. Japanese journal of clinical medicine · 2004
- [Digoxin].Nederlands tijdschrift voor geneeskunde · 1988
via PubMed
Wikidata facts
- Mass
- 780.43
Show 6 more facts
- chemical formula
- C₄₁H₆₄O₁₄
- Commons category
- Digoxin
- isomeric SMILES
- C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5C[C@H]([C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)O)C)C)C)O)O
- canonical SMILES
- CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CC(C7(C6(CCC7C8=CC(=O)OC8)O)C)O)C)C)C)O)O
- World Health Organisation international non-proprietary name
- digoxin
- defined daily dose
- 0.25
via Wikidata · CC0
~17 min read
Article
18 sectionsContents
- Medical uses
- Irregular heartbeat
- Heart failure
- Abortion
- Euthanasia
- Side effects
- Overdose
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Pharmacomicrobiomics
- History
- Society and culture
- Brand names
- Digoxin and cancer
- See also
- References
- Further reading
Digoxin, sold under the brand name Lanoxin among others, is a medication used to treat various heart conditions. Most frequently it is used for atrial fibrillation, atrial flutter, and heart failure. Digoxin is one of the oldest medications used in the field of cardiology. It works by increasing myocardial contractility, increasing stroke volume and blood pressure, reducing heart rate, and somewhat extending the time frame of the contraction. Digoxin is taken by mouth or by injection into a vein. Digoxin has a half life of approximately 36 hours given at average doses in patients with normal renal function. It is excreted mostly unchanged in the urine.
Common side effects include breast enlargement with other side effects generally due to an excessive dose. These side effects may include loss of appetite, nausea, trouble seeing, confusion, and an irregular heartbeat. Greater care is required in older people and those with poor kidney function. It is unclear whether use during pregnancy is safe.