diphenoxylate

Also known as 4-ethoxycarbonyl-alpha,alpha,4-triphenyl-1-piperidinebutyronitrile, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-isonipecotic acid ethyl ester, ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylate, ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotate, 2,2-diphenyl-4-(4-carbethoxy-4-phenylpiperidino)butyronitrile

Diphenoxylate is a centrally active opioid drug of the phenylpiperidine series that is used as a combination drug with atropine for the treatment of diarrhea. Diphenoxylate is an opioid and acts by slowing intestinal contractions; the atropine is present to prevent drug abuse and overdose. It should not be given to children due to the risk that they will stop breathing and should not be used in people with Clostridioides difficile infection.

Research

472 papers

Diphenoxylate.2012
Diphenoxylate.2006
Diphenoxylate and Atropine.2026
Opioids, Opioid Antagonists.2012
Diphenoxylate-atropine (Lomotil) overdose in children: an update (report of eight cases and review of the literature).Pediatrics · 1991

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Wikidata facts

Subclass of: chemical compound
Mass: 452.246
Has use: medication

Show 7 more facts

chemical formula: C₃₀H₃₂N₂O₂
canonical SMILES: CCOC(=O)C1(CCN(CC1)CCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4
defined daily dose: 15.0
World Health Organisation international non-proprietary name: diphenoxylate
subject has role: antidiarrhoeal
MCN code: 2933.33.41
Commons category: Diphenoxylate

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Encyclopedic overview

9 sections

Contents

Medical use
Adverse effects
Pharmacology
History and chemistry
Society and culture
Pricing
Regulation
Research
References

==Medical use== Diphenoxylate is used to treat diarrhea in adults; it is only available as a combination drug with a subtherapeutic dose of atropine to prevent abuse.

Excerpted from Wikipedia’s “diphenoxylate” article, available under the CC BY-SA 4.0 licence.

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